1- Fundamental immunology: study of the repertoire of the immune response at the level of the antigen specific receptors of the T lymphocytes and antibodies, and at the level of the regulation of the inflammation and immune responses by dendritic cells and complement system. 2- Immunology in chronic diseases: study of the immune system regulation and deregulation in Viral Hepatitis infections, liver cancer and diseases, inflammatory diseases induced by Human RetroVirus, to define diagnostic/prognostic markers and to assay new therapies. 3- Nano Bio Technology: development of miniaturised tools for analysis of the immune system by protein and cell chip to be used in the frame of medical diagnostic and prognostic; evaluation effects of nano materials and particles on the immune system that may lead to chronic inflammatory diseases or may be used for therapies of the immune system and vaccines.