Dr. Pablo Alberto Romagnoli
CIMETSA-CONICET, Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC), Córdoba, Argentina
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Academic Career Length
27Years (2000-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 July 2013 in Immunity
Journal Article
BSBrian S. Sheridan
Brian S. Sheridan
Pablo Alberto RomagnoliQPQuynh-Mai Pham
Quynh-Mai Pham
HFHan-Hsuan Fu
Han-Hsuan Fu
FAFrancis Alonzo
Francis Alonzo
LLLeo Lefrançois
Leo Lefrançois +2
13 October 2017 in Science Immunology
Journal Article
OPOriana A. Perez
Oriana A. PerezSYStephen T. Yeung
Stephen T. YeungPVPaola Vera-Licona
Paola Vera-LiconaPablo Alberto RomagnoliTSTasleem Samji
Tasleem SamjiKKKamal M. Khanna
Kamal M. Khanna +3
CD169 + macrophages in the spleen play an essential role in the clearance of Listeria monocytogenes .
Journal Article
JDJose Debes
Jose DebesPablo Alberto RomagnoliJPJhon Prieto
Jhon PrietoMAMarco Arrese
Marco ArreseAMAngelo Z. Mattos
Angelo Z. MattosOCon behalf of the ESCALON Consortium
on behalf of the ESCALON Consortium
+1
Hepatocellular carcinoma (HCC) is a leading cause of global cancer death. Major etiologies of HCC relate to chronic viral infections as well as metabolic conditions. The survival rate of people with HCC is very low and has been attributed to late diagnosis with limited treatment options. Combining ultrasound and the biomarker alpha-fetoprotein (AFP) is currently one of the most widely used screening combinations for HCC. However, the clinical utility of AFP is controversial, and the frequency and operator-dependence of ultrasound lead to a variable degree of sensitivity and specificity across the globe. In this review, we summarize recent developments in the search for non-invasive serum biomarkers for early detection of HCC to improve prognosis and outcome for patients. We focus on tumor-associated protein markers, immune mediators (cytokines and chemokines), and micro-RNAs in serum or circulating extracellular vesicles and examine their potential for clinical application.
11 July 2016 in Proceedings of the National Academy of Sciences
Journal Article
Pablo Alberto RomagnoliBSBrian S. Sheridan
Brian S. Sheridan
QPQuynh-Mai Pham
Quynh-Mai Pham
LLLeo Lefrançois
Leo Lefrançois
KKKamal M. Khanna
Kamal M. KhannaSignificance: Outbreaks of food-borne infections with Listeria monocytogenes can result in high mortality. Using a model of recombinant L. monocytogenes that models human infection in mice, we show that L. monocytogenes -specific memory γδ T cells in fact represent a resident memory (Trm) population in the mesenteric lymph node that secrete IL-17A and cluster with L. monocytogenes replication foci after secondary infection. Furthermore γδ Trms mediate the intranodal migration and redistribution of myeloid cells, which was necessary to contain the spread and growth of L. monocytogenes . Our findings demonstrate how γδ Trm cells orchestrate pathogen-induced innate immune responses. These observations provide the rationale for designing novel vaccination strategies to harness the ability of γδ Trm cells to provide protection against intestinal pathogens.
18 February 2013 in PLOS ONE
Journal Article
Pablo Alberto RomagnoliMPMary F. Premenko-Lanier
Mary F. Premenko-Lanier
GLGilbert D. Loria
Gilbert D. Loria
JAJohn D. Altman
John D. AltmanProtection against many intracellular pathogens is provided by CD8 T cells, which are thought to need CD4 T cell help to develop into effective memory CD8 T cells. Because murine CD8 T cells do not transcribe MHC class II (MHC-II) genes, several models have proposed antigen presenting cells (APCs) as intermediaries required for CD4 T cells to deliver their help to CD8 T cells. Here, we demonstrate the presence of MHC-II molecules on activated murine CD8 T cells in vitro as well as in vivo. These MHC-II molecules are acquired via trogocytosis by CD8 T cells from their activating APCs, particularly CD11c positive dendritic cells (DCs). Transferred MHC-II molecules on activated murine CD8 T cells were functionally competent in stimulating specific indicator CD4 T cells. CD8 T cells that were “helped” in vitro and subsequently allowed to rest in vivo showed enhanced recall responses upon challenge compared to “helpless” CD8 T cells; in contrast, no differences were seen upon immediate challenge. These data indicate that direct CD8∶CD4 T cell interactions may significantly contribute to help for CD8 T cells. Furthermore, this mechanism may enable CD8 T cells to communicate with different subsets of interacting CD4 T cells that could modulate immune responses.
27 July 2016 in Mucosal Immunology
Journal Article
Pablo Alberto RomagnoliHFH.H. Fu
H.H. Fu
ZQZ. Qiu
Z. Qiu
CKC. Khairallah
C. KhairallahQPQ.M. Pham
Q.M. Pham
BSBrian Sheridan
Brian Sheridan +3
Mucosal antigen-specific CD4 T-cell responses to intestinal pathogens remain incompletely understood. Here we examined the CD4 T-cell response after oral infection with an internalin A ‘murinized’ Listeria monocytogenes (Lm). Oral Lm infection induced a robust endogenous listeriolysin O (LLO)-specific CD4 T-cell response with distinct phenotypic and functional characteristics in the intestine. Circulating LLO-specific CD4 T cells transiently expressed the ‘gut-homing’ integrin α4β7 and accumulated in the intestinal lamina propria and epithelium where they were maintained independent of interleukin (IL)-15. The majority of intestinal LLO-specific CD4 T cells were CD27− Ly6C− and CD69+ CD103− while the lymphoid LLO-specific CD4 T cells were heterogeneous based on CD27 and Ly6C expression and predominately CD69−. LLO-specific effector CD4 T cells transitioned into a long-lived memory population that phenotypically resembled their parent effectors and displayed hallmarks of residency. In addition, intestinal effector and memory CD4 T cells showed a predominant polyfunctional Th1 profile producing IFNγ, TNFα, and IL-2 at high levels with minimal but detectable levels of IL-17A. Depletion of CD4 T cells in immunized mice led to elevated bacterial burden after challenge infection highlighting a critical role for memory CD4 T cells in controlling intestinal intracellular pathogens.
About Me
Pablo A. Romagnoli, PhD, is a researcher (Investigador Adjunto) with the National Scientific and Technical Research Council (CONICET), based at Centro de Investigación en Medicina Traslacional "Severo R. Amuchástegui" (CIMETSA), a CONICET-associated unit of the Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC), Córdoba, Argentina. He obtained his B.S. in Biochemistry (Bioquímico Clínico) from the Universidad Nacional de Córdoba and his PhD in Immunology and Molecular Pathogenesis from Emory University (Atlanta, GA, USA), followed by postdoctoral training in mucosal immunology at UConn Health (Farmington, CT, USA) under Dr. Leo Lefrançois and Dr. Kamal M. Khanna. His research focuses on T cell memory, gut microbiota, and dietary metabolites in inflammatory bowel disease, and he has authored more than 27 peer-reviewed publications in journals such as PNAS, Immunity, and Mucosal Immunology. He has served as principal investigator or collaborator on numerous national and international research grants, including funding from FONCYT/ANPCyT, the Chan Zuckerberg Initiative, and the European Commission's Horizon 2020 program. He is a member of the Sociedad Argentina de Inmunología, the Latin American Mucosal Immunology Group, and the Society for Mucosal Immunology, and has received several international travel and research awards throughout his career.
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