Patrick C. Bradshaw is an
Associate Professor in the Department of Biomedical Sciences at East Tennessee
State University. He received his B.S. in Bioengineering from the University of
Illinois-Urbana and earned his Ph.D. in Biochemistry from The Ohio State
University. He was also a postdoctoral fellow at the University of Missouri (2001–2003), Virginia
Tech (2003–2005), and the University of Wisconsin–Madison (2005–2007). His
research interests include mechanisms of mitochondrial dysfunction in aging and
neurodegenerative diseases; mechanisms of dietary restriction-induced longevity; the role of NADPH and redox imbalance in aging; RNAi screening using C. elegans nematodes to
identify genes mediating aging-induced mitochondrial dysfunction; and metabolic
therapies with select amino acids, ketone bodies, and citric acid cycle
intermediates for the treatment of aging-associated disorders.
Research Keywords & Expertise
Aging
Alzheimer's Disease
Amino Acids
C. elegans
Exercise
Metabolism
pyruvate
NAD+
NADPH
Parkinson's disease
alpha-ketoglutarate
fasting
longevity medicine
beta-hydroxybutyrate
Fingerprints
53%
Aging
53%
Metabolism
32%
Amino Acids
27%
Alzheimer's Disease
22%
NAD+
16%
C. elegans
16%
pyruvate
16%
NADPH
16%
Parkinson's disease
16%
fasting
11%
beta-hydroxybutyrate
6%
Exercise
Short Biography
Patrick C. Bradshaw is an
Associate Professor in the Department of Biomedical Sciences at East Tennessee
State University. He received his B.S. in Bioengineering from the University of
Illinois-Urbana and earned his Ph.D. in Biochemistry from The Ohio State
University. He was also a postdoctoral fellow at the University of Missouri (2001–2003), Virginia
Tech (2003–2005), and the University of Wisconsin–Madison (2005–2007). His
research interests include mechanisms of mitochondrial dysfunction in aging and
neurodegenerative diseases; mechanisms of dietary restriction-induced longevity; the role of NADPH and redox imbalance in aging; RNAi screening using C. elegans nematodes to
identify genes mediating aging-induced mitochondrial dysfunction; and metabolic
therapies with select amino acids, ketone bodies, and citric acid cycle
intermediates for the treatment of aging-associated disorders.