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Prof. Patrick C. Bradshaw

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Patrick C. Bradshaw is an Associate Professor in the Department of Biomedical Sciences at East Tennessee State University. He received his B.S. in Bioengineering from the University of Illinois-Urbana and earned his Ph.D. in Biochemistry from The Ohio State University. He was also a postdoctoral fellow at the University of Missouri (2001–2003), Virginia Tech (2003–2005), and the University of Wisconsin–Madison (2005–2007). His research interests include mechanisms of mitochondrial dysfunction in aging and neurodegenerative diseases; mechanisms of dietary restriction-induced longevity; the role of NADPH and redox imbalance in aging; RNAi screening using C. elegans nematodes to identify genes mediating aging-induced mitochondrial dysfunction; and metabolic therapies with select amino acids, ketone bodies, and citric acid cycle intermediates for the treatment of aging-associated disorders.

Research Keywords & Expertise

Aging
Alzheimer's Disease
Amino Acids
C. elegans
Exercise

Fingerprints

53%
Aging
53%
Metabolism
32%
Amino Acids
27%
Alzheimer's Disease
22%
NAD+
16%
C. elegans

Short Biography

Patrick C. Bradshaw is an Associate Professor in the Department of Biomedical Sciences at East Tennessee State University. He received his B.S. in Bioengineering from the University of Illinois-Urbana and earned his Ph.D. in Biochemistry from The Ohio State University. He was also a postdoctoral fellow at the University of Missouri (2001–2003), Virginia Tech (2003–2005), and the University of Wisconsin–Madison (2005–2007). His research interests include mechanisms of mitochondrial dysfunction in aging and neurodegenerative diseases; mechanisms of dietary restriction-induced longevity; the role of NADPH and redox imbalance in aging; RNAi screening using C. elegans nematodes to identify genes mediating aging-induced mitochondrial dysfunction; and metabolic therapies with select amino acids, ketone bodies, and citric acid cycle intermediates for the treatment of aging-associated disorders.