Impaired wound healing is one of the unsolved problems of modern medicine, affecting patients’ quality of life and causing serious economic losses. Impaired wound healing can manifest itself in the form of chronic skin wounds or hypertrophic scars. Research on the biology and physiology of skin wound healing disorders is actively continuing, but, unfortunately, a single understanding has not been developed. The attention of clinicians to the biological and physiological aspects of wound healing in the skin is necessary for the search for new and effective methods of prevention and treatment of its consequences. In addition, it is important to update knowledge about genetic and non-genetic factors predisposing to impaired wound healing in order to identify risk levels and develop personalized strategies for managing such patients. Wound healing is a very complex process involving several overlapping stages and involving many factors. This thematic review focuses on the extracellular matrix of the skin, in particular its role in wound healing. The authors analyzed the results of fundamental research in recent years, finding promising potential for their transition into real clinical practice.

Dupuytren’s disease is a multifactorial polygenic disease accompanied by hand deformity with flexion contracture of the fingers. Despite the improvement of surgical treatment methods for this disease, the rate of postoperative relapses is high and can reach a third of cases or more. A search of scientific literature in databases was conducted using keywords and their combinations to analyze and systematize methodological approaches to the use of scales and questionnaires for patients with Dupuytren’s disease. 28 scales and questionnaires were found and analyzed, but only 11 of them correspond to the purpose of this study and can be recommended for use in real clinical practice. We divided these scales into four groups. Many diagnostic scales and questionnaires, on the one hand, expands the capabilities of the orthopedic traumatologist in diagnosing and assessing the dynamics of disease progression, but on the other hand, each of the analyzed scales separately does not make it possible to comprehensively assess the associated parameters. At the same time, the use of several scales on an outpatient basis and in a 24-hour hospital setting takes quite a lot of time.