Overall, the purpose of my research work is to understand macromolecular complexes associated with human diseases related to cancer and antimicrobial resistance using structural, biochemical and biophysical approaches for developing therapeutics. My area of focus has been on macromolecular complexes that get altered in cancer patients and secondary infections associated with the immunocompromised state of these patients. In this aspect, I have studied oxidative stress biology (both bacteria and human), human transcription related to cancer and antibiotic resistance and bacterial virulence, related to secondary infections in cancer patients. Structural techniques like X-ray crystallography and CryoEM along with biophysical and biochemical methods are mainly implemented for this purpose. The long-term goals are to develop deliverables and therapeutics that have target-specific action with selective toxicity. In this aspect, I have a keen interest in developing phages as therapeutics, targeted protein degradation, peptides and chemical compounds inhibiting rate-limiting enzymes, RNA therapeutics and protein engineering for repurposing metabolic fates.