My long-term research interest is identifying the molecular link between alteration in gut-microbiota and the risk of developing cardiovascular disorders. My academic training at multiple institutions provided me with a robust foundation in physiology, molecular biology, and cardiovascular biology. As a doctoral fellow, I investigated how gaseous mediators contribute to the pathogenesis of polymicrobial sepsis. I discovered that the overactivation of hydrogen sulfide (H2S) signaling alters the expression of key genes involved in the inflammatory process during sepsis. We were the first to discover that H2S regulates the liver sieve porosity during sepsis and its clinical relevance. During my postdoctoral studies, I investigated the microRNA–microbiota interaction in myocardial hypertrophy and endothelial function. I discovered that cardiac miR-204 plays a cardioprotective role in the heart, and its effects are mediated via APJ signaling regulation. Recently, I spearheaded the investigation that aimed to determine the translational suitability of gamma-modified peptide nucleic acid-based miR-122 inhibitor in improving vascular endothelial function in prediabetic mice.
Research Keywords & Expertise
Diabetes
Obesity
Maternal obesity
cardiac dysfunction
MicroRNAs (miRNAs)
Gut-microbiota
Heart Failure (HF)
Fingerprints
8%
Diabetes
8%
Obesity
5%
cardiac dysfunction
Short Biography
My long-term research interest is identifying the molecular link between alteration in gut-microbiota and the risk of developing cardiovascular disorders. My academic training at multiple institutions provided me with a robust foundation in physiology, molecular biology, and cardiovascular biology. As a doctoral fellow, I investigated how gaseous mediators contribute to the pathogenesis of polymicrobial sepsis. I discovered that the overactivation of hydrogen sulfide (H2S) signaling alters the expression of key genes involved in the inflammatory process during sepsis. We were the first to discover that H2S regulates the liver sieve porosity during sepsis and its clinical relevance. During my postdoctoral studies, I investigated the microRNA–microbiota interaction in myocardial hypertrophy and endothelial function. I discovered that cardiac miR-204 plays a cardioprotective role in the heart, and its effects are mediated via APJ signaling regulation. Recently, I spearheaded the investigation that aimed to determine the translational suitability of gamma-modified peptide nucleic acid-based miR-122 inhibitor in improving vascular endothelial function in prediabetic mice.
Well done!
