Dr. João Vicente Braga Sousa
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Academic Career Length
24Years (2003-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications13 August 2022 in International Journal of Microbiology
Journal Article
FFFlávia da Silva Fernandes
Flávia da Silva Fernandes
ÉSÉrica Simplício de Souza
Érica Simplício de Souza
LCLívia Melo Carneiro
Lívia Melo Carneiro
João SilvaJoão Vicente Braga SousaJBJacqueline da Silva Batista
Jacqueline da Silva Batista
An increase in global energy demand has caused oil prices to reach record levels in recent times. High oil prices together with concerns over CO2 emissions have resulted in renewed interest in renewable energy. Nowadays, ethanol is the principal renewable biofuel. However, the industrial need for increased productivity, wider substrate range utilization, and the production of novel compounds leads to renewed interest in further extending the use of current industrial strains by exploiting the immense, and still unknown, potential of natural yeast strains. This review seeks to answer the following questions: (a) which characteristics should S. cerevisiae have for the current production of first- and second-generation ethanol? (b) Why are alcohol-tolerance and thermo-tolerance characteristics required? (c) Which genes are related to these characteristics? (d) What are the advances that can be achieved with the isolation of new organisms from the environment?
1 April 2014 in Process Biochemistry
Journal Article
JCJessyca dos Reis Celestino
Jessyca dos Reis Celestino
LCLoretta Ennes de Carvalho
Loretta Ennes de Carvalho
MLMaria Da Paz Lima
Maria Da Paz LimaALAlita Moura Lima
Alita Moura Lima
MOMauricio Morishi Ogusku
Mauricio Morishi Ogusku
João Vicente Braga Sousa14 April 2021 in International Journal of Microbiology
Journal Article
MSMichele Alves Sanches
Michele Alves Sanches
ILIsabella Galvão Luzeiro
Isabella Galvão Luzeiro
ACAna Cláudia Alves Cortez
Ana Cláudia Alves Cortez
ÉSÉrica Simplício de Souza
Érica Simplício de Souza
Patrícia Melchionna AlbuquerqueJoão Vicente Braga Sousa +1
Surfactants are utilized to reduce surface tension in aqueous and nonaqueous systems. Currently, most synthetic surfactants are derived from petroleum. However, these surfactants are usually highly toxic and are poorly degraded by microorganisms. To overcome these problems associated with synthetic surfactants, the production of microbial surfactants (called biosurfactants) has been studied in recent years. Most studies investigating the production of biosurfactants have been associated mainly with bacteria and yeasts; however, there is emerging evidence that those derived from fungi are promising. The filamentous fungi ascomycetes have been studied for the production of biosurfactants from renewable substrates. However, the yield of biosurfactants by ascomycetes depends on several factors, such as the species, nutritional sources, and environmental conditions. In this review, we explored the production, chemical characterization, and application of biosurfactants by ascomycetes.
1 January 2020 in Revista da Sociedade Brasileira de Medicina Tropical
Journal Article
MSMonique Freire Santana
Monique Freire Santana
GPGuilherme Pivoto
Guilherme Pivoto
MAMárcia A. Araujo Alexandre
Márcia A. Araujo Alexandre
DBDjane Baia
Djane BaiaMBMayla Gabriela Silva Borba
Mayla Gabriela Silva BorbaMLMarcus Vinícius Guimarães de Lacerda
Marcus Vinícius Guimarães de Lacerda +14
We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomannan antigen testing confirmed IPA. Aspergillus penicillioides infection was confirmed by nucleotide sequencing and BLAST analysis. Further reports are needed to assess the occurrence and frequency of IPA in SARS-CoV-2 infections, and how they interact clinically.
24 April 2018 in International Journal of Microbiology
Journal Article
HSHellen Holanda Sena
Hellen Holanda Sena
MSMichele Alves Sanches
Michele Alves SanchesDRDiego Fernando Silva Rocha
Diego Fernando Silva Rocha
WSWalter Oliva Pinto Filho Segundo
Walter Oliva Pinto Filho SegundoÉSÉrica Simplício de Souza
Érica Simplício de SouzaJoão Vicente Braga SousaBiosurfactants are surface-active compounds that have sparked interest in recent years because of their environmental advantages over conventional surfactants. The aim of this study was to investigate the production of biosurfactants by soil fungi isolated from the Amazon forest. Fungi colonies were isolated from soil samples and screened for biosurfactant production in submerged fermentation. In addition, the influences of bioprocess factors (carbon source, nitrogen source, pH, and fermentation time) were investigated. Finally, the biosurfactant produced was semipurified and submitted to stability tests. One hundred fungal cultures were obtained from the soil samples, identified by micromorphology, and submitted to screening for biosurfactant production. Sixty-one strains produced biosurfactants. The strainPenicillium8CC2 showed the highest emulsification index (54.2%). The optimized bioprocess conditions for biosurfactant production byPenicillium8CC2 were as follows: soybean oil, 20 g/L; yeast extract, 30 g/L; pH 9; duration of 9 days. The semipurified biosurfactant showed stability after heating at 100°C for 60 min and after the addition of 30% NaCl (w/v). Tween 80 (0.2% w/v), a conventional surfactant, was used as the control.
23 March 2016 in Mycoses
Journal Article
GAGleica Soyan Barbosa Alves
Gleica Soyan Barbosa Alves
AFAna Karla Lima Freire
Ana Karla Lima Freire
ABAmaury dos Santos Bentes
Amaury dos Santos Bentes
JPJosé Felipe de Souza Pinheiro
José Felipe de Souza Pinheiro
João Vicente Braga SousaAJAni Beatriz Jackisch‐Matsuura
Ani Beatriz Jackisch‐Matsuura +2
About Me
He holds a degree in Pharmacy from the University of Amazonas (2000), a specialization in Biotechnology from the Federal University of Lavras (2005), a Ph.D. in Industrial Biotechnology from the University of São Paulo School of Engineering of Lorena (2004), and a Postdoctoral fellowship in Biotechnology from Cranfield University, UK (2014). He has worked as a Biotechnologist at the National Institute of Amazonian Research (INPA) since 2009. His research focuses on the fungal production of bioactive compounds of pharmaceutical interest (including antifungals, biosurfactants, and colorants) and the development of molecular tools applied to the diagnosis and characterization of agents causing invasive mycoses. He has authored 91 articles in peer-reviewed scientific journals. He is a permanent faculty member of the Graduate Program in Pharmaceutical Sciences at UFAM, the Bionorte Graduate Program in Biodiversity and Biotechnology, and the Graduate Program in Genetics, Conservation, and Evolutionary Biology at INPA. He has supervised 9 Ph.D. theses, co-supervised 3 Ph.D. theses, advised 24 Master's dissertations, and mentored 37 undergraduate research projects. Currently, he supervises 6 Ph.D. students, 5 Master's students, and 2 undergraduate researchers. In terms of scientific and technological contributions to innovation, he has participated in the development of four biotechnological processes. Regarding project management, he currently coordinates four projects funded by FAP