Dr. Sara Ragucci
Department of Environmental, Biological and Pharmaceutical Sciences and Technologie(DiSTABiF), University of Campania ‘Luigi Vanvitelli’, Via Vivaldi 43, I-81100 Caserta, Italy
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Academic Career Length
12Years (2015-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
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Journal Article
Cow, sheep and goat raw milk raised in Ailano and Valle Agricola territories (‘Alto Casertano’, Italy) were characterized (raw proteins, free and total amino acids content) to assess milk quality. Raw milk with the highest total protein content is sheep milk followed by goat and cow milk from both localities. Total amino acid content in cow, goat and sheep raw milk is 4.58, 4.81 and 6.62 g per 100 g, respectively, in which the most abundant amino acid is glutamic acid (~20.36 g per 100 g of proteins). Vice versa, the free amino acids content characteristic profiles are different for each species. In particular, the most abundant free amino acid in cow, sheep and goat raw milk is glutamic acid (9.07 mg per 100 g), tyrosine (4.72 mg per 100 g) and glycine (4.54 mg per 100 g), respectively. In addition, goat raw milk is a source of taurine (14.92 mg per 100 g), retrieved in low amount in cow (1.38 mg per 100 g) and sheep (2.10 mg per 100 g) raw milk. Overall, raw milk from ‘Alto Casertano’ show a high total protein content and are a good source of essential amino acids.
Journal Article
Nicola LandiACAngela Clemente
Angela Clemente
Paolo Vincenzo PedoneSara Ragucci
Antimo Di MaroHere, we report the current status of the bioactive peptides isolated and characterized from mushrooms during the last 20 years, considering ‘peptide’ a succession from to 2 to 100 amino acid residues. According to this accepted biochemical definition, we adopt ~10 kDa as the upper limit of molecular weight for a peptide. In light of this, a careful revision of data reported in the literature was carried out. The search revealed that in the works describing the characterization of bioactive peptides from mushrooms, not all the peptides have been correctly classified according to their molecular weight, considering that some fungal proteins (>10 kDa MW) have been improperly classified as ‘peptides’. Moreover, the biological action of each of these peptides, the principles of their isolation as well as the source/mushroom species were summarized. Finally, this review highlighted that these peptides possess antihypertensive, antifungal, antibiotic and antimicrobial, anticancer, antiviral, antioxidant and ACE inhibitory properties.
1 May 2017 in Biochimica et Biophysica Acta (BBA) - General Subjects
Journal Article
NLNicola Landi
Nicola Landi
SPSeverina Pacifico
Severina Pacifico
Sara Ragucci
Rosario IglesiasSPSimona Piccolella
Simona Piccolella
Antimo Di Maro +2
28 May 2019 in ACS Chemical Biology
Journal Article
LUCIA CITORESSara Ragucci
José Miguel FerrerasAntimo Di MaroRosario IglesiasJournal Article
Sara RagucciNicola LandiRRRosita Russo
Rosita RussoMVMariangela Valletta
Mariangela VallettaPaolo Vincenzo PedoneAntimo Di Maro +1
Ageritin is a specific ribonuclease, extracted from the edible mushroom Cyclocybe aegerita (synonym Agrocybe aegerita), which cleaves a single phosphodiester bond located within the universally conserved alpha-sarcin loop (SRL) of 23–28S rRNAs. This cleavage leads to the inhibition of protein biosynthesis, followed by cellular death through apoptosis. The structural and enzymatic properties show that Ageritin is the prototype of a novel specific ribonucleases family named ‘ribotoxin-like proteins’, recently found in fruiting bodies of other edible basidiomycetes mushrooms (e.g., Ostreatin from Pleurotus ostreatus, Edulitins from Boletus edulis, and Gambositin from Calocybe gambosa). Although the putative role of this toxin, present in high amount in fruiting body (>2.5 mg per 100 g) of C. aegerita, is unknown, its antifungal and insecticidal actions strongly support a role in defense mechanisms. Thus, in this review, we focus on structural, biological, antipathogenic, and enzymatic characteristics of this ribotoxin-like protein. We also highlight its biological relevance and potential biotechnological applications in agriculture as a bio-pesticide and in biomedicine as a therapeutic and diagnostic agent.
1 July 2018 in Biochimica et Biophysica Acta (BBA) - Biomembranes
Journal Article
EPElio Pizzo
Elio Pizzo
KPKATIA PANE
KATIA PANEABAndrea Bosso
Andrea Bosso
NLNicola Landi
Nicola Landi
Sara RagucciAntimo Di Maro +7
About Me
Sara Ragucci obtained her master’s degree in biology (Summa cum laude with distinction) at the University of Campania “L. Vanvitelli”. She did a research period abroad at the Laboratory of Biochemistry and Molecular Biology, University of Valladolid (Spain) under the supervision of Prof. José Miguel Ferreras. In 2018, she obtained her PhD in Biomolecular Sciences with the additional title of Doctor Europaeus at DiSTABiF, alternating periods of research abroad. Dr. Ragucci was a post-doc at DiSTABiF in the ‘Protein Biochemistry’ group. Since February 2023, she has been holding the National Scientific Habilitation for the position of associate professor in the Sector 05/E1-GENERAL BIOCHEMISTRY (BIOS-07/A). Since 1 October 2024, Dr. Ragucci has been an assistant professor in biochemistry at DiSTABiF. Her research activity is mainly focused on the isolation and structural and functional characterization of enzymes of biotechnological interest, as well as hemoproteins used as a possible molecular marker to detect food fraud. She is also involved in the biochemical–nutritional characterization aimed at enhancing typical products from the Campania Region. She has participated as an invited speaker at several congresses, is a member of the Italian Society of Biochemistry and Molecular Biology, and is a member of the editorial board of several international journals related to SSD BIOS-07/A.