Siddharth Bhatia

Dr. Siddharth Bhatia

Centre for Cellular and Molecular Biology, Hyderabad, India
Snake venom researcher

Biography

I have pursued my PhD from Centre for cellular and molecular biology. I looked at intraspecific snake venom variation and how it impacts the efficacy of Indian Polyvalent Antivenom. I collected E. carinatus venoms from 3 different states- Tamil Nadu, Rajasthan and Goa, and performed venom proteomics using Tandem mass spectrometry. We observed considerable variation in venom composition across these locations. We expected that this venom variation might impact Antivenom's efficacy, which is produced using venoms sourced only from a single location which is based in Tamil Nadu. To test this hypothesis, we checked the binding and neutralization capacity of antivenom against venoms from Goa and Rajasthan, and compared it with that of Tamil Nadu. We found that the efficacy of the antivenom was less for venoms from Goa and Rajasthan. Our work emphasizes the need for evaluating venoms from different locations and pooling them to improve the efficacy of antivenom. After submission of my Phd thesis, I worked as a Research Scientist in an Antivenom manufacturing company- VINS Bioproducts Ltd. I was involved in simplifying the protocols for testing the preclinical efficacy of routine antisera products. My research interests include snake venom proteomics, toxin evolution and antivenomics.

Affiliations

Centre for Cellular and Molecular Biology

Hyderabad, India

Honors and Awards

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Experience

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