Sten Rasmussen’s (SR) main research theme is knee osteoarthritis, pain, sports injuries, and arthroscopic surgery. The main scientific approach is the randomized controlled trial. There are more than 10 clinical randomized double-blind controlled investor-initiated trials with SR as the PI or the senior investigator. SR has great insight into a broad spectrum of relevant scientific approaches including proteomics, big data, and machine learning. The most publication is on knee disorders. The research in knee joint osteoarthritis, inflammation, and pain has led to more than 30 publications within the last 5-10 years, 1 in NEJM (NEJM 2015 Oct 22; 373: 1597-606).