Vítor Costa

Prof. Vítor Costa

Universidade do Porto, Porto, Portugal
orcid

Research Focus & Metrics

Academic Career Length

35Years (1992-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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9 August 2010 in Proceedings of the National Academy of Sciences
Verified
Journal Article
Closed access
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AMAna Mesquita
Ana Mesquita
MWMartin Weinberger
Martin Weinberger
ASAlexandra Silva
Alexandra Silva
BSBelém Sampaio-Marques
Belém Sampaio-Marques
BABruno Almeida
Bruno Almeida
Paula LudovicoPaula Ludovico
Paula Ludovico
The free radical theory of aging posits oxidative damage to macromolecules as a primary determinant of lifespan. Recent studies challenge this theory by demonstrating that in some cases, longevity is enhanced by inactivation of oxidative stress defenses or is correlated with increased, rather than decreased reactive oxygen species and oxidative damage. Here we show that, in Saccharomyces cerevisiae , caloric restriction or inactivation of catalases extends chronological lifespan by inducing elevated levels of the reactive oxygen species hydrogen peroxide, which activate superoxide dismutases that inhibit the accumulation of superoxide anions. Increased hydrogen peroxide in catalase-deficient cells extends chronological lifespan despite parallel increases in oxidative damage. These findings establish a role for hormesis effects of hydrogen peroxide in promoting longevity that have broad implications for understanding aging and age-related diseases.


1 February 1996 in Molecular Microbiology
Verified
Journal Article
Closed access
PDF file
PMP. Moradas‐Ferreira
P. Moradas‐Ferreira
VCVítor Costa
Vítor Costa
PPP. Piper
P. Piper
WMW. Mager
W. Mager

1 January 2018 in Microbial Cell
Verified
Journal Article
Open access
DCDidac Carmona-Gutierrez
Didac Carmona-Gutierrez
MBMaria Anna Bauer
Maria Anna Bauer
AZAndreas Zimmermann
Andreas Zimmermann
AAAndrés Aguilera
Andrés Aguilera
NANicanor Austriaco
Nicanor Austriaco
FMFrank Madeo
Frank Madeo
Guidelines and recommendations on yeast cell death nomenclature – Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cellular demise. However, the investigation of yeast cell death is a relatively young field, and a widely accepted set of concepts and terms is still missing. Here, we propose unified criteria for the definition of accidental, regulated, and programmed (...)

27 February 2007 in Journal of Agricultural and Food Chemistry
Verified
Journal Article
Closed access
IBIracema Belinha
Iracema Belinha
MAMaria Amélia Amorim
Maria Amélia Amorim
PRPedro Rodrigues
Pedro Rodrigues
VFVitor De Freitas
Vitor De Freitas
PMPedro Moradas-Ferreira
Pedro Moradas-Ferreira
VCVítor Costa
Vítor Costa

1 December 2002 in Free Radical Biology and Medicine
Verified
Journal Article
Closed access
VCVítor Costa
Vítor Costa
MAMaria Amélia Amorim
Maria Amélia Amorim
AQAlexandre Quintanilha
Alexandre Quintanilha
PMPedro Moradas-Ferreira
Pedro Moradas-Ferreira