Wee Sim Choo completed a Bachelor of Science in Food Studies (2001) with a First Class Honours and a Master of Science (2004) in the field of Food Chemistry and Biochemistry from the Universiti Putra Malaysia. She then joined the Malaysian Palm Oil Board as a research officer before moving to the University of Otago, New Zealand to complete a Ph.D. in Food Science in 2008. She joined the Faculty of Applied Sciences, UCSI University soon after and then the School of Science, Monash University Malaysia in 2009. In 2013 she obtained a Graduate Certificate in Higher Education from Monash University. She has been awarded three PVC Awards for Excellence in Teaching (2010-2011) and one PVC Commendation for Excellence in Education - Innovations in Teaching (2020). She also received the PVC Commendation for Excellence in Research – Postgraduate Supervision in 2024, Most Popular Supervisor in Monash University Malaysia, and Supervisor of the Year of the School of Science awards in 2022 from the Monash University Postgraduate Association (MUPA). She was an Outstanding Nominee for the Best Supervisor of the Year Award in 2018. Her current research interests focus on functional foods which are foods that potentially offer health benefits beyond basic nutrition. She was on Stanford University's list of the World's Top 2% of Scientists in 2024.