Wiebren Markus

Dr. Wiebren Markus

IrisZorg, Arnhem, Gelderland, The Netherlands
+2
orcid

Research Focus & Metrics

Academic Career Length

11Years (2016-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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27 March 2019 in Drug and Alcohol Review
Verified
Journal Article
Open access
PDF file
CBCarolien Bruijnen
Carolien Bruijnen
BDBoukje Dijkstra
Boukje Dijkstra
SWSerge J. W. Walvoort
Serge J. W. Walvoort
Wiebren MarkusWiebren Markus
Wiebren Markus
JVJoanne VanDerNagel
Joanne VanDerNagel
CJCornelis A. J. DE Jong
Cornelis A. J. DE Jong
Introduction and Aims: Cognitive impairments in substance use disorder predict treatment outcome and are assumed to differ between substances. They often go undetected, thus the current study focuses on the prevalence of and differences in cognitive functioning across substances by means of a cognitive screen at the early stage of addiction treatment.Design and Methods: The Montreal Cognitive Assessment was administered to outpatients seeking treatment for substance use disorder. Patient characteristics (age, years of regular use, polysubstance use, severity of dependence/abuse, depression, anxiety and stress) were also taken into account.Results: A total of 656 patients were included (n = 391 used alcohol, n = 123 used cannabis, n = 100 used stimulants and n = 26 used opioids). The prevalence of cognitive impairments was 31%. Patients using alcohol had a lower total‐ and memory domain score than those using cannabis. Patients using opioids scored lower on visuospatial abilities than those using cannabis or stimulants. Younger patients scored higher than older patients. No effect was found for the other investigated characteristics.Discussion and Conclusions: Given the high prevalence of cognitive impairments, standard screening at an early stage of treatment is important to determine the course of treatment and maximise treatment outcome. Caution is needed in interpreting results about opioids due to an underrepresentation of this patient group, and more research is needed on the effect of age on Montreal Cognitive Assessment performance.

1 September 2016 in Journal of Behavior Therapy and Experimental Psychiatry
Verified
Journal Article
Closed access
Wiebren MarkusWiebren Markus
Wiebren Markus
GOGerdien H. de Weert – van Oene
Gerdien H. de Weert – van Oene
MWMarcella L. Woud
Marcella L. Woud
EBEni S. Becker
Eni S. Becker
CDCornelis A.J. DeJong
Cornelis A.J. DeJong

22 November 2019 in Alcohol, Clinical and Experimental Research
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Journal Article
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Wiebren MarkusWiebren Markus
Wiebren Markus
HHHellen K. Hornsveld
Hellen K. Hornsveld
WBWilliam J. Burk
William J. Burk
GOGerdien H. de Weert – van Oene
Gerdien H. de Weert – van Oene
EBEni S. Becker
Eni S. Becker
CDCornelis A.J. DeJong
Cornelis A.J. DeJong

4 June 2021 in PLOS ONE
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Journal Article
Open access
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JHJanika Heitmann
Janika Heitmann
MHMadelon E. van Hemel-Ruiter
Madelon E. van Hemel-Ruiter
MHMark Huisman
Mark Huisman
BOBrian D. Ostafin
Brian D. Ostafin
RWReinout W. Wiers
Reinout W. Wiers
PJPeter J. de Jong
Peter J. de Jong
Background: Attentional bias for substance-relevant cues has been found to contribute to the persistence of addiction. Attentional bias modification (ABM) interventions might, therefore, increase positive treatment outcome and reduce relapse rates. The current study investigated the effectiveness of a newly developed home-delivered, multi-session, internet-based ABM intervention, the Bouncing Image Training Task (BITT), as an add-on to treatment as usual (TAU). Methods: Participants (N = 169), diagnosed with alcohol or cannabis use disorder, were randomly assigned to one of two conditions: the experimental ABM group (50%; TAU+ABM); or the control group (50%; split in two subgroups the TAU+placebo group and TAU-only group, 25% each). Participants completed baseline, post-test, and 6 and 12 months follow-up measures of substance use and craving allowing to assess long-term treatment success and relapse rates. In addition, attentional bias (both engagement and disengagement), as well as secondary physical and psychological complaints (depression, anxiety, and stress) were assessed. Results: No significant differences were found between conditions with regard to substance use, craving, relapse rates, attentional bias, or physical and psychological complaints. Conclusions: The findings may reflect unsuccessful modification of attentional bias, the BITT not targeting the relevant process (engagement vs. disengagement bias), or may relate to the diverse treatment goals of the current sample (i.e., moderation or abstinence). The current findings provide no support for the efficacy of this ABM approach as an add-on to TAU in alcohol or cannabis use disorder. Future studies need to delineate the role of engagement and disengagement bias in the persistence of addiction, and the role of treatment goal in the effectiveness of ABM interventions.

1 January 2020 in Journal of EMDR Practice and Research
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Journal Article
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MMMarja van Minnen
Marja van Minnen
Wiebren MarkusWiebren Markus
Wiebren Markus
EBEric Blaauw
Eric Blaauw
Eye movement desensitization and reprocessing (EMDR) therapy is an evidence-based treatment for posttraumatic stress disorder (PTSD). Preliminary findings suggest the application of an adapted, addiction-focused EMDR procedure, AF-EMDR therapy, may also be helpful in treating addictions, such as gambling disorder (GD). In this study eight participants with GD received AF-EMDR therapy, using modules from Markus and Hornsveld's Palette of EMDR Interventions in Addiction (PEIA). A multiple baseline design was used to investigate whether AF-EMDR therapy reduced gambling urge and increased experienced self-control. Six weekly AF-EMDR sessions (treatment phase) were preceded by a 3- to 7-week non-treatment baseline phase. During both phases, participants kept a daily diary. Visual inspection as well as an interrupted time series analysis demonstrated mixed findings. Results showed that three participants experienced spontaneous recovery during the baseline period, two did not respond to treatment, and three others showed improvements during the EMDR phase. No adverse effects were noted. In sum, AF-EMDR therapy may have potential in the treatment of gambling addiction. However, more research is needed regarding the efficacy, contra-indications, focus, and application as well as the optimal dose of AF-EMDR therapy using the PEIA modules.

1 January 2019 in Journal of EMDR Practice and Research
Verified
Journal Article
Closed access
PDF file
Wiebren MarkusWiebren Markus
Wiebren Markus
CKCindy de Kruijk
Cindy de Kruijk
HHHellen K. Hornsveld
Hellen K. Hornsveld
GOGerdien H. de Weert–Van Oene
Gerdien H. de Weert–Van Oene
EBEni S. Becker
Eni S. Becker
CDCornelis A. J. DeJong
Cornelis A. J. DeJong
Alcohol use disorder (AUD) treatment presents a serious challenge. While there are evidence-based treatment options available, there is still a substantial group of treatment-seeking patients who do not complete regular AUD treatment. In addition, accomplished reductions in drinking behavior during treatment are often lost posttreatment. Therefore, both feasibility and effectiveness of AUD treatment are important. Innovative interventions, such as addiction-focused eye movement desensitization and reprocessing (AF-EMDR) therapy ( Markus & Hornsveld, 2017 ), may hold promise as adjunctive treatments. Here the results of a feasibility study of adjunctive AF-EMDR therapy in outpatients with AUD and without comorbid posttraumatic stress disorder (PTSD) are described. A multiple baseline design across four participants was used. They received AF-EMDR alongside treatment as usual (TAU). The results suggest that, while challenging, AF-EMDR therapy in outpatients with AUD can be safe, acceptable, and feasible. Whether it is effective, under what conditions and for whom, requires further study however.