The impact of COVID-19 has rendered medical technology an important factor to maintain social stability and economic increase, where biomedicine has experienced rapid development and played a crucial part in fighting off the pandemic. Conductive hydrogels (CHs) are three-dimensional (3D) structured gels with excellent electrical conductivity and biocompatibility, which are very suitable for biomedical applications. CHs can mimic innate tissue’s physical, chemical, and biological properties, which allows them to provide environmental conditions and structural stability for cell growth and serve as efficient delivery substrates for bioactive molecules. The customizability of CHs also allows additional functionality to be designed for different requirements in biomedical applications. This review introduces the basic functional characteristics and materials for preparing CHs and elaborates on their synthetic techniques. The development and applications of CHs in the field of biomedicine are highlighted, including regenerative medicine, artificial organs, biosensors, drug delivery systems, and some other application scenarios. Finally, this review discusses the future applications of CHs in the field of biomedicine. In summary, the current design and development of CHs extend their prospects for functioning as an intelligent and complex system in diverse biomedical applications.

Conductive polyacrylamide (PAM) hydrogels with salts that act as electrolytes have been used as transparent electrodes with high elasticity in flexible electronic devices. Different types and contents of raw materials will affect their performance in all aspects. We tried to introduce highly hydratable salts into PAM hydrogels to improve their water retention capacity. Different salts can improve the water retention capacity of PAM hydrogels to a certain extent. In particular, PAM hydrogels containing higher concentrations of lithium chloride (LiCl) and calcium chloride (CaCl₂) showed an extremely strong water retention capacity and could retain about 90% and more than 98% of the initial water in the experimental environment at a temperature of 25 °C and a relative humidity of 60% RH, respectively. In addition, we conducted electrical conductivity tests on these PAM hydrogels with different salts. The PAM hydrogels containing LiCl also show outstanding conductivity, and the highest conductivity value can reach up to about 8 S/m. However, the PAM hydrogels containing CaCl₂, which also performed well in terms of their water retention capacity, were relatively common in terms of their electrical conductivity. On this basis, we attempted to introduce single-walled carbon nanotubes (SWCNTs), multi-walled carbon nanotubes (MWCNTs), and graphene (GO) electronic conductors to enhance the electrical conductivity of the PAM hydrogels containing LiCl. The conductivity of the PAM hydrogels containing LiCl was improved to a certain extent after the addition of these electronic conductors. The highest electrical conductivity was about 10 S/m after we added the SWCNTs. This experimental result indicates that these electronic conductors can indeed enhance the electrical conductivity of PAM hydrogels to a certain extent. After a maximum of 5000 repeated tensile tests, the conductive hydrogel samples could still maintain their original morphological characteristics and conductivity. This means that these conductive hydrogel samples have a certain degree of system reliability. We made the PAM conductive hydrogels with high water retention and good conductivity properties into thin electrodes and applied them to an electric response flexible actuator with dielectric elastomer as the functional material. This flexible actuator can achieve a maximum area strain of 18% under an external voltage of 10 kV. This new composite hydrogels with high water retention and excellent conductivity properties will enable more possibilities for the application of hydrogels.

Polysaccharides have emerged as promising biomaterials for 3D bioprinting due to their inherent biocompatibility, biodegradability, and structural diversity. However, their limited mechanical strength, insufficient bioactivity, and suboptimal printability hinder their direct application in fabricating complex tissue constructs. This review systematically summarizes universal modification strategies to address these challenges by tailoring polysaccharides’ physicochemical and biological properties. We first analyse the fundamental requirements of bioprinting materials, emphasising on the critical role of shear-thinning behaviours, post-printing structural fidelity, and cell-instructive functions. Subsequently, we highlight the advantages and limitations of representative polysaccharides, including chitosan, alginate, and hyaluronic acid. Chemical functionalisation, physical reinforcement, and biological hybridisation are proposed as versatile approaches to synergistically enhance printability, mechanical robustness, and bioactivity to tackle the limitations. Furthermore, dynamic crosslinking mechanisms enabling self-healing and stimuli-responsive behaviours are discussed as emerging solutions for constructing biomimetic architectures. Finally, we outline future directions in balancing material processability with cellular viability and scaling up modified polysaccharides for clinical translation. This review aims to provide a design blueprint for engineering polysaccharide-based bioinks toward next-generation regenerative medicine.

Fundamentals of Massive MIMO - by Thomas L. Marzetta November 2016

Aiming to develop high-performance flexible electrode materials for dielectric elastomer actuation systems applied to micro-crawling robots, this study proposes multi-dimensional filler composite electrode materials with a methyl vinyl silicone rubber matrix. Three types of conductive fillers—namely, zero-dimensional super-conductive carbon black, one-dimensional single-walled carbon nanotubes, and two-dimensional flaky micron-sized silver powder—were employed to construct a hierarchical multi-dimensional conductive network within the silicone rubber matrix via a three-stage fabrication strategy. The electrical conductivity and conductive stability of the as-prepared composite electrode materials were systematically investigated, where the intrinsic mechanisms and evolutionary laws of material electrical performance variations were analyzed. Furthermore, the effects of fillers with different dimensional morphologies on the comprehensive properties of the composites at each fabrication stage were explored, and the optimal filler dosage for each component was determined. Microstructural observations of the staged conductive network formation further verified the rationality of the stage-based functional design model. The optimized composite electrode delivers an initial electrical conductivity of 1.5 × 10⁴ S/m, with only a 14.9% conductivity attenuation under 50% tensile strain, demonstrating excellent electromechanical stability. Moreover, a prototype micro-crawling robot was fabricated using the optimized composite electrode, achieving a maximum linear crawling speed of 8 mm/s. These experimental results validate the feasibility and superiority of the proposed multi-dimensional filler composite strategy. This work provides a novel technical approach for the design and development of high-performance flexible electrode materials for flexible electronic and micro-robotic actuation applications.