Background: Coronary heart disease (CHD) is one of the most common causes of morbidity and mortality in type 2 diabetes mellitus (T2DM). Oxidative stress is one of the important contributors to the pathogenesis of CHD. Sestrin2 is a stress-induced antioxidant protein that plays a important role in T2DM and CHD. However, the relationship between serum Sestrin2 levels and T2DM with CHD remains unclear.Aim: This study aimed to investigate the relationship between serum Sestrin2 levels and CHD in patients with type 2 diabetes.Methods: A total of 70 T2DM patients with CHD and 69 T2DM patients were enrolled in this study. Clinical features and metabolic indices were identified. Serum Sestrin2 was measured by ELISA.Results: Serum Sestrin2 levels in T2DM-CHD groups were significantly lower compared with the T2DM group (11.17 (9.79, 13.14) ng/mL vs 9.46 (8.34, 10.91) ng/mL). Bivariate correlation analysis revealed that serum Sestrin2 levels were negatively correlated with age (r = − 0.256,P = 0.002), BMI (r = − 0.206,P = 0.015), FBG (r = − 0.261,P = 0.002) and Tyg index (r = − 0.207,P < 0.014). Binary logistic regression suggested that low serum Sestrin2 levels were related to the increased risk of T2DM-CHD (P < 0.05). In addition, the receiver operating characteristic analysis revealed that the area under the curve of Sestrin2 was 0.724 (95% CI 0.641–0.808,P < 0.001) to predict T2DM-CHD patients (P < 0.001).Conclusion: The Sestrin2 levels were highly associated with CHD in diabetes patients. Serum Sestrin2 may be involved in the occurrence and development of diabetic with CHD.

The global outbreak of the COVID-19 epidemic has caused a considerable impact on humans, which expresses the urgency and importance of studying its impacts. Previous studies either frequently use aggregated research methods of statistic data or stay during COVID-19. The afterward impacts of COVID-19 on human behaviors need to be explored further. This article carries out a non-aggregated study methodology in human geography based on big data from social media comments and takes Nanjing, China, as the research case to explore the afterward impact of the COVID-19 epidemic on the spatial behavior of urban tourists. Precisely, we propose the methodology covers two main aspects regarding travel contact trajectory and spatial trajectory. In contact trajectory, we explore three indicators—Connection Strength, Degree Centrality, and Betweenness Centrality—of the collected attractions. Then, in spatial trajectory, we input the results from contact trajectory into ArcGIS by using the Orientation–Destination Model and Standard Deviation Ellipse to explore the influences on the spatial pattern. By setting up comparative groups for the three periods of before, during, and after the COVID-19 in Nanjing, this study found that, in the post-epidemic era, (1) the spatial behavior of urban tourists showed a state of overall contraction; (2) the objects of contraction changed from urban architectural attractions to urban natural attractions; (3) the form of contraction presents concentric circles with the central city (Old City of Nanjing) as the core; (4) the direction of contraction heads to the large-scale natural landscape in the central city, which highlights the importance of green open spaces in the post-epidemic era.

This paper unravels the new multi-relational rescaling of state-level new areas (SNAs) in China’s up-to-date city-region-building. These nationwide SNAs have created an unimpeded governance pathway among multi-level governments and multi-scalar localities. As proofed by our empirical study on the establishment history of Jiangbei SNA, this new pathway has consolidated the re-centralization, reconfiguration, and re-marketization tools that can be adopted as comprehensive governance approaches by the state to resolve the long-term dilemma in city-regional governance since the incremental development in the 1990s characterized by frequent failure on administrative intervention, ungrounded regional strategies, and disordered inter-city competitions. Furthermore, the successful practice at Jiangbei SNA can function as a positive reference for developing China’s city-regions towards a region-in-becoming so that national initiatives in city-region-building can be dynamically adjusted accordingly.