Zoltán Molnár

Prof. Zoltán Molnár

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, Oxfordshire, UK
orcid
Professor of Developmental Neuroscience at University of Oxf...

Research Focus & Metrics

Academic Career Length

37Years (1990-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2017 in Cell Reports
Verified
Journal Article
Open access
KAKatharine Askew
Katharine Askew
KLKaizhen Li
Kaizhen Li
AOAdrian Olmos-Alonso
Adrian Olmos-Alonso
FGFernando Garcia-Moreno
Fernando Garcia-Moreno
YLYajie Liang
Yajie Liang
DGDiego Gomez-Nicola
Diego Gomez-Nicola
Microglia play key roles in brain development, homeostasis, and function, and it is widely assumed that the adult population is long lived and maintained by self-renewal. However, the precise temporal and spatial dynamics of the microglial population are unknown. We show in mice and humans that the turnover of microglia is remarkably fast, allowing the whole population to be renewed several times during a lifetime. The number of microglial cells remains steady from late postnatal stages until aging and is maintained by the spatial and temporal coupling of proliferation and apoptosis, as shown by pulse-chase studies, chronic in vivo imaging of microglia, and the use of mouse models of dysregulated apoptosis. Our results reveal that the microglial population is constantly and rapidly remodeled, expanding our understanding of its role in the maintenance of brain homeostasis.

1 February 2008 in Neuron
Verified
Journal Article
Closed access
OBOlga Britanova
Olga Britanova
Camino de Juan RomeroCamino de Juan Romero
Camino de Juan Romero
ACAmanda Cheung
Amanda Cheung
KKKenneth Y. Kwan
Kenneth Y. Kwan
MSManuela Schwark
Manuela Schwark
VTVictor Tarabykin
Victor Tarabykin

18 February 2011 in Nature Reviews Neuroscience
Verified
Journal Article
Closed access
PDF file
ENEdward A. Neuwelt
Edward A. Neuwelt
BBBjörn Bauer
Björn Bauer
CFChristoph Fahlke
Christoph Fahlke
Gert FrickerGert Fricker
Gert Fricker
CIConstantino Iadecola
Constantino Iadecola
LDLester R. Drewes
Lester R. Drewes

19 December 2001 in Nature Neuroscience
Verified
Journal Article
Closed access
PDF file
PWPhilip Washbourne
Philip Washbourne
PTPeter M. Thompson
Peter M. Thompson
MCMario Carta
Mario Carta
ECEdmar T. Costa
Edmar T. Costa
JMJames R. Mathews
James R. Mathews
MWMichael C. Wilson
Michael C. Wilson

1 April 2003 in Nature Reviews Neuroscience
Verified
Journal Article
Closed access
GLGuillermina López-Bendito
Guillermina López-Bendito
Zoltán MolnárZoltán Molnár
Zoltán Molnár

1 January 2007 in Cell
Verified
Journal Article
Open access
DKDavid A. Keays
David A. Keays
GTGuoling Tian
Guoling Tian
KPKarine Poirier
Karine Poirier
GHGuo-Jen Huang
Guo-Jen Huang
CSChristian Siebold
Christian Siebold
JFJonathan Flint
Jonathan Flint
The development of the mammalian brain is dependent on extensive neuronal migration. Mutations in mice and humans that affect neuronal migration result in abnormal lamination of brain structures with associated behavioral deficits. Here, we report the identification of a hyperactive N-ethyl-N-nitrosourea (ENU)-induced mouse mutant with abnormalities in the laminar architecture of the hippocampus and cortex, accompanied by impaired neuronal migration. We show that the causative mutation lies in the guanosine triphosphate (GTP) binding pocket of alpha-1 tubulin (Tuba1) and affects tubulin heterodimer formation. Phenotypic similarity with existing mouse models of lissencephaly led us to screen a cohort of patients with developmental brain anomalies. We identified two patients with de novo mutations in TUBA3, the human homolog of Tuba1. This study demonstrates the utility of ENU mutagenesis in the mouse as a means to discover the basis of human neurodevelopmental disorders.