The presence of persistent contaminants in soils is of growing concern around the world. Contaminated soils can affect numerous ecological environments and lead to significant health risks to humans, affecting soil biodiversity, structure and geomechanical behaviour and agricultural sustainability. Additionally, soil contaminants can also leach into water flows, which is another concern. In general, soil contamination can be attributed to natural sources or to anthropogenic sources associated with human activity. Soil contaminants are usually classified in the following categories: biological, radioactive, organic and inorganic contaminants. State of the art information regarding some of the most common persistent soil contaminants, including possible sources and prevalence, and monitoring approaches and information about their effects on soil characteristics, including usability, as well as information on possible mobility to other environmental media is presented in this review paper. Finally, a comprehensive overview of remediation strategies which are being developed, including the more traditional ones as well as novel strategies that have been proposed lately by the scientific community, is provided. This includes physicochemical and biological technologies, as well as mixed remediation technologies aimed at enhancing remediation efficiency.