Machine learning models have gained popularity nowadays for their potential to solve real-life issues when trained on pertinent data. In many cases, the real-life data are class imbalanced and hence the corresponding machine learning models trained on the data tend to perform poorly on metrics like precision, recall, AUC, F1, and G-mean score. Since class imbalance issue poses serious challenges to the performance of trained models, a multitude of research works have addressed this issue. Two common data-based sampling techniques have mostly been proposed-undersampling the data of the majority class and oversampling the data of the minority class. In this article, we focus on the former approach. We propose two novel algorithms that employ neural network-based approaches to remove majority samples that are found to reside in the vicinity of the minority samples, thereby undersampling the former to remove (or alleviate) the imbalance issue. We delineate the proposed algorithms and then test the proposed algorithms on some publicly available imbalanced datasets. We then compare the performance of our proposed algorithms to other popular undersampling algorithms. Finally, we conclude that our proposed algorithms outperform most of the existing undersampling approaches on most performance metrics.

Retrieval-augmented generation (RAG) systems combine the strengths of language generation and information retrieval to power many real-world applications like chatbots. Use of RAG for understanding of videos is appealing but there are two critical limitations. One-time, upfront conversion of all content in large corpus of videos into text descriptions entails high processing times. Also, not all information in the rich video data is typically captured in the text descriptions. Since user queries are not known apriori, developing a system for video to text conversion and interactive querying of video data is challenging. To address these limitations, we propose an incremental RAG system called iRAG, which augments RAG with a novel incremental workflow to enable interactive querying of a large corpus of videos. Unlike traditional RAG, iRAG quickly indexes large repositories of videos, and in the incremental workflow, it uses the index to opportunistically extract more details from select portions of the videos to retrieve context relevant to an interactive user query. Such an incremental workflow avoids long video to text conversion times, and overcomes information loss issues due to conversion of video to text, by doing on-demand query-specific extraction of details in video data. This ensures high quality of responses to interactive user queries that are often not known apriori. To the best of our knowledge, iRAG is the first system to augment RAG with an incremental workflow to support efficient interactive querying of a large corpus of videos. Experimental results on real-world datasets demonstrate 23x to 25x faster video to text ingestion, while ensuring that latency and quality of responses to interactive user queries is comparable to responses from a traditional RAG where all video data is converted to text upfront before any user querying.

Epigenetic aging has been found to be associated with a number of phenotypes and diseases. A few studies have investigated its effect on lung function in relatively older people. However, this effect has not been explored in the younger population. This study examines whether lung function in adolescence can be predicted with epigenetic age accelerations (AAs) using machine learning techniques. DNA methylation based AAs were estimated in 326 matched samples at two time points (at 10 years and 18 years) from the Isle of Wight Birth Cohort. Five machine learning regression models (linear, lasso, ridge, elastic net, and Bayesian ridge) were used to predict FEV₁ (forced expiratory volume in one second) and FVC (forced vital capacity) at 18 years from feature selected predictor variables (based on mutual information) and AA changes between the two time points. The best models were ridge regression (R² = 75.21% ± 7.42%; RMSE = 0.3768 ± 0.0653) and elastic net regression (R² = 75.38% ± 6.98%; RMSE = 0.445 ± 0.069) for FEV₁ and FVC, respectively. This study suggests that the application of machine learning in conjunction with tracking changes in AA over the life span can be beneficial to assess the lung health in adolescence.