Purpose: This randomized, double-blind, placebo-controlled trial investigated the effects of Curcuma longa extract (CLE) supplementation on vascular, redox-inflammatory biomarkers, and neuropathy symptoms in adults with type 2 diabetes mellitus (T2DM). Methods: Seventy-six adults with T2DM were randomized to receive CLE (1200 mg/day) or placebo for three months. Plasma concentrations of hyaluronic acid (HA), syndecan-1 (SDC1), syndecan-4 (SDC4), matrix metalloproteinases (MMP-2 and MMP-9), thioredoxin-1 (Trx1), thioredoxin-binding protein-2 (TBP2), sirtuin-1 (SIRT1), nuclear factor erythroid 2–related factor 2 (Nrf2), and the p65 subunit of nuclear factor kappa B (NF-κB p65) were measured at baseline and post-intervention. Neuropathy symptoms were assessed using a validated questionnaire. Results: Baseline characteristics were comparable between groups. After 3 months, CLE supplementation resulted in a significant reduction in neuropathy symptom score compared with placebo ( P = 0.048). CLE significantly reduced markers of endothelial glycocalyx shedding, including SDC1 (66.5 vs. 113.0 ng/mL; P = 0.001), SDC4 (155.1 vs. 225.5 pg/mL; P = 0.040), and HA (259.8 vs. 371.7 ng/mL; P = 0.002), as well as MMP-2 (198.4 vs. 233.3 ng/mL; P < 0.001) and MMP-9 (1.2 vs. 2.0 ng/mL; P < 0.001). In parallel, CLE increased antioxidant/redox markers Trx1, SIRT1, and Nrf2 (all P < 0.05) and reduced TBP2 and NF-κB p65 levels (both P < 0.001), indicating coordinated modulation of vascular, redox, and inflammatory pathways. Conclusion: Short-term supplementation with CLE was associated with favorable modulation of vascular and redox-inflammatory biomarkers and improvement in neuropathy symptoms in adults with T2DM. These findings support the role of CLE as a promising bioactive nutritional supplement for the prevention and management of vascular and neuropathic complications associated with diabetes.

The compound odontoma, classified as an odontogenic tumor, with the highest incidence rates, representing up to 70% of all odontogenic tumors found. It is a benign tumor, composed of odontogenic epithelium with odontogenic ectomesenchyme. Its histology presents with different dental tissues, including enamel, dentin, cementum, and, in some cases, pulp tissue. Therapy consists of surgical excision. This case report aimed to describe the step-by-step surgical procedure for removing a compound odontoma in a pediatric patient, and thereby emphasize the importance of early and conclusive diagnosis, as well as its treatment plan. An 8-year-old male patient with the absence of eruption of teeth 11 and 12 and prolonged retention of tooth 52. The diagnosis and surgical procedure were thorough and precise. During the patient's 7-month follow-up, there was no spontaneous eruption of the teeth. Therefore, diagnosing and investigating clinical, radiographic, and tomographic situations suggestive of odontomas are essential to avoid damage to the permanent dentition and the timeline of tooth eruption.

Introduction/Objectives: Dental caries is a significant public health burden in Brazil, with regional disparities deeply affecting children in the North and Northeast. This study assessed the prevalence and severity of dental caries in preschool children from Balsas (MA) and investigated its association with fluoride concentrations in the public water supply. Methods: A cross-sectional study was conducted with 256 children (aged 3–5 years) enrolled in municipal schools. Schools were selected using a stratified sampling strategy based on the water network, with exposure validated via chemical analysis. Calibrated dentists performed examinations using the FOA-UNESP risk scale, assessing biofilm and gingivitis as objective clinical proxies for hygiene. Fluoride levels were analyzed using an ion-selective electrode. Statistical analysis included Fisher’s exact test, Kruskal–Wallis, and Multiple Correspondence Analysis (MCA). Results: Caries prevalence was 60.16%, with 41.8% of children in severe risk categories (F: 27.0%; G: 14.8%). Water analysis revealed universal hypofluoridation (0.02–0.34 µg F/mL). A significant association was found between residual fluoride (0.02 µg F/mL) and greater caries severity (p = 0.04). Poor hygiene markers (biofilm and gingivitis) were significantly associated with a higher number of decayed teeth (p < 0.05). MCA identified a cluster linking residual fluoridation to severe clinical conditions and social vulnerability. Conclusions: High caries prevalence associated with inadequate fluoridation highlights critical regional health inequalities in Balsas. These findings underscore the urgent need for policies ensuring universal water fluoridation and strengthening school-based preventive strategies to mitigate the impact of social determinants on child development.