The rising prevalence of antibiotic resistance underscores the need for localized drug delivery systems that minimize systemic exposure. Autologous platelet concentrates (APCs), including concentrated platelet-rich fibrin (c-PRF) and liquid-phase concentrated growth factors (LPCGFs), have emerged as potential carriers for antimicrobial agents. This study aimed to evaluate the efficacy of c-PRF and LPCGF as carriers for three antibiotic formulations—amoxicillin with clavulanic acid, clindamycin, and a combination of amoxicillin with metronidazole—against methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), and Enterococcus faecalis (low-level natural resistance). The disk diffusion method was employed to incorporate antibiotics into both APC types, which were then applied to disks placed on bacterial cultures. The size of the inhibition zones was measured at 20-, 40-, 60-, and 80-h intervals. Every 20 h, the disks were transferred to a new Petri dish. Statistical analysis included Welch’s t-test and two-way ANOVA. c-PRF demonstrated superior performance as a carrier for amoxicillin and clindamycin, showing the presence of inhibition zones for up to 60 h. In contrast, LPCGF exhibited greater efficacy when used with the amoxicillin–metronidazole combination, particularly at higher concentrations. Both APCs showed limited effectiveness against E. faecalis when combined with clindamycin. The study confirms the suitability of autologous platelet concentrates as localized antibiotic delivery systems. The choice between c-PRF and LPCGF should be guided by the drug’s physicochemical properties and clinical application. APCs offer a promising alternative for targeted antimicrobial therapy in dental and surgical settings.

Background: Fungal infections, particularly those caused by Candida species, pose a serious threat to immunocompromised individuals, and therapeutic options are limited due to toxicity and resistance concerns. This in vitro study aimed to explore the feasibility of using liquid fractions of autologous platelet concentrates (APCs), namely concentrated platelet-rich fibrin (c-PRF) and liquid-phase concentrated growth factor (LPCGF), as carriers for antifungal drugs. Methods: The research was conducted in two phases: first, to evaluate the inherent antifungal properties of different APCs; and second, to assess their effectiveness as drug carriers for fluconazole and voriconazole against Candida albicans, Candida glabrata, and Candida krusei. Results: Results showed that APCs alone exhibited no direct antifungal effects. However, when combined with antifungal agents, notable inhibition zones were observed—especially with voriconazole against C. krusei and fluconazole against C. glabrata using c-PRF. Both c-PRF and LPCGF were compatible with the drugs and did not hinder clot formation. Conclusions: These findings suggest that APCs can act as effective vehicles for localized antifungal drug delivery and warrant further investigation for clinical application in treating fungal-related oral diseases.

The amniotic membrane, which lacks blood vessels, lymphatic vessels and nerves, is a thin membrane with anti-inflammatory and anti-scarring properties. In the field of dentistry, it is primarily employed as a dressing following the removal of malignant or pre-malignant lesions, with the objective of ensuring haemostasis and the absence of allergic reactions. Furthermore, it is employed in the treatment of oro-auricular junctions, cleft palates and in guided bone regeneration, due to the presence of mesenchymal cells. In vestibuloplasty, it has been demonstrated to enhance vestibular deepening, accelerate epithelialisation and reduce pain. In periodontics, it has been shown to be an effective treatment for gingival recession and furcation defects, and to increase the width of keratinised gingiva around implants. In endodontics, it is employed in regenerative procedures, offering comparable results to standard methods. Furthermore, in the treatment of osteoarthritis of the temporomandibular joint, it has been observed to provide pain relief and improved joint function.

Aim: Iodine is an essential nutrient for the synthesis of thyroid hormones. It has a huge impact on the normal brain development of the foetus and the health of the pregnant woman. During pregnancy and lactation, the need for iodine increases significantly. This review aims to summarize the role of iodine supplementation in addressing these elevated demands and preventing associated health risks. Materials and Methods: The review is based on the thorough analysis of the materials selected from “PubMed” and “Google Scholar” scientific databases using the following key words: iodine; pregnant; lactation; supplementation. These key words were chosen based on their relevance to the matter of the article. Conclusions: Iodine supplementation is essential for optimal maternal and foetal health. However, comprehensive strategies are needed to address iodine deficiency, including public education on iodine-rich diets, policy initiatives on salt iodisation and minimising exposure to harmful chemicals in the environment. These measures can affect the health of pregnant and lactating women and their children. Moreover, the paper discusses the potential implications of excessive iodine intake, which may lead to thyroid dysfunction. This review underlines the crucial role of interdisciplinary collaboration in ensuring optimal maternal and neonatal health outcomes.

People with autism spectrum disorder (ASD) often face many difficulties when trying to get dental care. These challenges are caused by their unique health needs, behavior differences, and trouble with communication. Many individuals with ASD need help from caregivers to keep up with daily routines like brushing and flossing, which may not always be done regularly. They may also have picky eating habits that increase the risk of tooth decay. In some cases, they may not be able to tell others when they are in pain or need help with a dental problem. Going to the dentist can be very stressful for people with ASD. The loud sounds, bright lights, and unfamiliar tools in dental offices can cause fear or anxiety. Some dental clinics are not set up to support patients with special needs, which makes the visit even harder. Also, many dentists and staff members do not have enough training to care for patients with autism. This paper aims to look at the problems people with ASD face in getting dental care and to suggest ways to make dental visits easier and better for them. Improving access and comfort can help people with ASD have healthier teeth and a better quality of life.

Introduction and objective: Vitamin D is essential for overall health, and particularly of the musculoskeletal system, including teeth. Its deficiency is linked to many oral health issues, such as caries susceptibility, impaired odontogenesis, delayed teeth eruption, implant failure and...