Healthcare supply chains are complex structures spanning across multiple organizational and geographical boundaries, providing critical backbone to services vital for everyday life. The inherent complexity of such systems can introduce impurities including inaccurate information, lack of transparency and limited data provenance. Counterfeit drugs is one consequence of such limitations within existing supply chains which not only has serious adverse impact on human health but also causes severe economic loss to the healthcare industry. Consequently, existing studies have emphasized the need for a robust, end-to-end track and trace system for pharmaceutical supply chains. Therein, an end-to-end product tracking system across the pharmaceutical supply chain is paramount to ensuring product safety and eliminating counterfeits. Most existing track and trace systems are centralized leading to data privacy, transparency and authenticity issues in healthcare supply chains. In this article, we present an Ethereum blockchain-based approach leveraging smart contracts and decentralized off-chain storage for efficient product traceability in the healthcare supply chain. The smart contract guarantees data provenance, eliminates the need for intermediaries and provides a secure, immutable history of transactions to all stakeholders. We present the system architecture and detailed algorithms that govern the working principles of our proposed solution. We perform testing and validation, and present cost and security analysis of the system to evaluate its effectiveness to enhance traceability within pharmaceutical supply chains.

Metaverse has the potential to reshape and transform the way people interact and perform their daily tasks. A metaverse is a virtual, digital, and three-dimensional universe formed by integrating different cutting-edge technologies and virtual places. In this article, we discuss how the metaverse can be utilized in healthcare. We provide insightful discussions on the concept of the metaverse and its main enabling technologies. We explore and discuss the potential applications of the metaverse in healthcare, such as telemedicine and telehealth, medical education and training, medical marketing, healthcare supply chain, healthcare facilities, and fitness and wellness. We present the key challenges hindering the widespread adoption of the metaverse in healthcare. Finally, we recommend future research directions.

Distribution and delivery of Coronavirus 2019 (COVID-19) vaccines have become challenging after their emergence. Today’s platforms and systems leveraged for managing data related to COVID-19 vaccines’ distribution and delivery fall short in providing transparency, trackability and traceability, immutability, audit, and trust features. Also, they are vulnerable to the single point of failure problem due to centralization. Such limitations hindering the safe, secure, transparent, trustworthy, and reliable distribution and delivery process of COVID-19 vaccines. In this paper, we propose an Ethereum blockchain-based solution for managing data related to COVID-19 vaccines’ distribution and delivery. We develop smart contracts to automate the traceability of COVID-19 vaccines while ensuring data provenance, transparency, security, and accountability. We integrate the Ethereum blockchain with off-chain storage to manage non-critical and large-sized data. We present algorithms and discuss their full implementation, testing, and validation details. We evaluate the proposed solution by performing cost and security analysis as well as comparing it with the existing non-blockchain and blockchain-based solutions. Performance evaluation results reveal that the proposed solution is low-cost, and our smart contracts are secure enough against possible attacks and vulnerabilities. The smart contracts code along with testing scripts is made publicly available.

The COVID-19 pandemic caused disruption in the healthcare market, which resulted in shortages of essential healthcare products. The pandemic exacerbated the problems that already existed in the healthcare supply chain, such as poor data availability, transparency, and accessibility. Such problems necessitate the introduction of a solution that is capable of managing products, maintaining ownership, facilitating trading, and delivering products in a traceable, auditable, and trustworthy manner. In this article, we propose a nonfungible-token-based solution for the management of healthcare products, where the ownership of a product is maintained by using digital certification, the trade and delivery of healthcare products is facilitated by a smart contract, and disputes are settled by an arbitrator while keeping all related information on-chain for auditing purposes. We utilize the Interplanetary File System to store the metadata of healthcare products to avoid storing large-sized data on the blockchain. We present system diagrams and algorithms along with the implementation details. We conduct security testing to demonstrate that our solution is resilient and secure against common vulnerabilities and exploits. We compare our solution with the existing solutions to show its distinctive features and novelty. The smart contracts code is made publicly available on GitHub.

Nonfungible tokens (NFTs) have emerged as one of the most popular digital assets in recent years. They represent ownership of unique items that are stored on a blockchain and cannot be changed, replaced, or copied. Digital exchanges sell and trade NFT-minted assets that can only have one official owner at a time. NFTs are entering all sectors, from art to real estate, and healthcare is the next sector. In this article, we envision using NFTs in healthcare. We present the main components along with key features of NFTs and their benefits. We discuss the potential opportunities brought about by NFTs in different healthcare areas, such as supply chain management, patient-centric data management, digital twins, clinical trial management, and genomics. We discuss some important challenges hindering the adoption of NFTs in healthcare, serving as future research directions.