Prof. Dr. Andreas Melzer
Professor of Computer Assisted Surgery and Director of ICCAS at the University of Leipzig, Germany
+3
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Academic Career Length
34Years (1993-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications30 April 2014 in Physical Review Letters
Journal Article
CDChristine E. M. Démoré
Christine E. M. Démoré
PDPatrick M. Dahl
Patrick M. Dahl
ZYZhengyi Yang
Zhengyi YangPGPeter Glynne-Jones
Peter Glynne-JonesAndreas MelzerGSGabriel C. Spalding
Gabriel C. Spalding +2
Negative radiation forces act opposite to the direction of propagation, or net momentum, of a beam but have previously been challenging to definitively demonstrate. We report an experimental acoustic tractor beam generated by an ultrasonic array operating on macroscopic targets () to demonstrate the negative radiation forces and to map out regimes over which they dominate, which we compare to simulations. The result and the geometrically simple configuration show that the effect is due to nonconservative forces, produced by redirection of a momentum flux from the angled sides of a target and not by conservative forces from a potential energy gradient. Use of a simple acoustic setup provides an easily understood illustration of the negative radiation pressure concept for tractor beams and demonstrates continuous attraction towards the source, against a net momentum flux in the system.
1 June 2011 in Radiology
Journal Article
SZStephan Zangos
Stephan ZangosAndreas MelzerKEKatrin Eichler
Katrin Eichler
CSCyrus Sadighi
Cyrus Sadighi
ATAxel Thalhammer
Axel Thalhammer
TVThomas J. Vogl
Thomas J. Vogl
+7
Our results showed that robot-assisted MR-guided transgluteal biopsy of the prostate gland in a high-field-strength MR system is a promising technique in patients with suspicious prostate lesions, elevated prostate specific antigen levels, and negative findings at transrectal US-guided biopsy. PurposeTo examine the feasibility and safety of magnetic resonance (MR)-guided biopsy by using a transgluteal approach in patients with suspicious prostate lesions by using an MR-compatible robotic system and a 1.5-T MR system.Materials and MethodsThe study was approved by the institutional review board of University Frankfurt, and informed consent was obtained from each patient. A total of 20 patients (age range, 57.8–71.9 years; mean age, 65.1 years) underwent biopsy in a closed-bore high-field-strength MR system. Biopsy was performed with an MR-compatible pneumatically driven robotic system. T1-weighted gradient-echo fast low-angle shot and T2-weighted true fast imaging with steady-state precession sequences were used to plan and guide the intervention with a transgluteal access on the external planning computer of the assistance system. The system calculated the trajectory and then moved the guiding arm to the insertion point. The cannula was advanced manually, and biopsies were performed with the coa...
1 September 2013 in Journal of Controlled Release
Journal Article
DGDana Gourevich
Dana GourevichODOsnat Dogadkin
Osnat Dogadkin
AVAlexander Volovick
Alexander Volovick
LWLijun Wang
Lijun Wang
JGJallal Gnaim
Jallal Gnaim
Andreas Melzer +1
Journal Article
SHShaonan Hu
Shaonan HuXZXinrui Zhang
Xinrui ZhangMUMichael Unger
Michael UngerIPIna Patties
Ina PattiesAndreas MelzerLLLisa Landgraf
Lisa LandgrafFocused ultrasound (FUS) has become an important non-invasive therapy for solid tumor ablation via thermal effects. The cavitation effect induced by FUS is thereby avoided but applied for lithotripsy, support drug delivery and the induction of blood vessel destruction for cancer therapy. In this study, head and neck cancer (FaDu), glioblastoma (T98G), and prostate cancer (PC-3) cells were exposed to FUS by using an in vitro FUS system followed by single-dose X-ray radiation therapy (RT) or water bath hyperthermia (HT). Sensitization effects of short FUS shots with cavitation (FUS-Cav) or without cavitation (FUS) to RT or HT (45 °C, 30 min) were evaluated. FUS-Cav significantly increases the sensitivity of cancer cells to RT and HT by reducing long-term clonogenic survival, short-term cell metabolic activity, cell invasion, and induction of sonoporation. Our results demonstrated that short FUS treatment with cavitation has good potential to sensitize cancer cells to RT and HT non-invasively.
12 July 2021 in Frontiers in Robotics and AI
Journal Article
Image guidance is a common methodology of minimally invasive procedures. Depending on the type of intervention, various imaging modalities are available. Common imaging modalities are computed tomography, magnetic resonance tomography, and ultrasound. Robotic systems have been developed to enable and improve the procedures using these imaging techniques. Spatial and technological constraints limit the development of versatile robotic systems. This paper offers a brief overview of the developments of robotic systems for image-guided interventions since 2015 and includes samples of our current research in this field.
Journal Article
LLLisa Landgraf
Lisa LandgrafAKAdam Kozlowski
Adam KozlowskiXZXinrui Zhang
Xinrui ZhangMFMarc Fournelle
Marc FournelleFBFranz Josef Becker
Franz Josef BeckerAndreas Melzer +1
Focused ultrasound (FUS) is a non-invasive technique producing a variety of biological effects by either thermal or mechanical mechanisms of ultrasound interaction with the targeted tissue. FUS could bring benefits, e.g., tumour sensitisation, immune stimulation, and targeted drug delivery, but investigation of FUS effects at the cellular level is still missing. New techniques are commonly tested in vitro on two-dimensional (2D) monolayer cancer cell culture models. The 3D tumour model—spheroid—is mainly utilised to mimic solid tumours from an architectural standpoint. It is a promising method to simulate the characteristics of tumours in vitro and their various responses to therapeutic alternatives. This study aimed to evaluate the effects of FUS on human prostate and glioblastoma cancer tumour spheroids in vitro. The experimental follow-up enclosed the measurements of spheroid integrity and growth kinetics, DNA damage, and cellular metabolic activity by measuring intracellular ATP content in the spheroids. Our results showed that pulsed FUS treatment induced molecular effects in 3D tumour models. With the disruption of the spheroid integrity, we observed an increase in DNA double-strand breaks, leading to damage in the cancer cells depending on the cancer cell type.
About Me
Prof. Dr. Andreas Melzer is the current Executive Director of the Innovation Center Computer Assisted Surgery (ICCAS) in Leipzig, Germany, and the Division Leader of the research team on Computer Assisted Image-Guided Interventions within the organization. In the early 1990s, he successfully graduated in Dentistry and Medicine from the University Mainz and University Tübingen and early on discovered his aptitude towards the development of medical technology for interventional radiology, laparo-endoscopic surgery and interventional and intraoperative MRI image guided robotics. Since then, Andreas Melzer can look back at more than 200 patents and over 300 peer-reviewed publications in the field. He is also the co-founder and partner of six start-up companies and a consultant to many major vendors in the medical technology business. Prof. Melzer’s academic career spans four continents, where his latest appointment is as a Visiting Professor at the National Cancer Center Graduate School of Cancer Science and Policy in Seoul, South Korea. He has been elected a board member of many reputable German and International societies in the medical technology field, among them the German Society for Biomedical Engineering (BMT) and the International Society for Medical Innovation and Technology (iSMIT). His long standing excellence and valuable contributions to medicine have earned him a Fellowship of the British Academy of Medical Sciences in 2019.