I serve as Director of the Thrombosis and Vascular Biology Program and as Principal Investigator of the NHLBI funded T32 Program in Hematology & Cell Biology of Blood Cells at the University of Iowa. I lead a multidisciplinary research environment that integrates thrombosis, inflammation, and metabolism to investigate mechanisms of vascular injury and immune mediated thrombotic disease. For more than 15 years, my laboratory has produced field shaping discoveries that established new conceptual frameworks in thromboinflammation. Key contributions include: (1) defining the antithrombotic functions of ADAMTS13, leading to patented therapeutic approaches; (2) establishing the ADAMTS13–von Willebrand factor axis as a central regulator of thromboinflammatory injury; and (3) identifying PKM2 as a critical immunometabolic regulator of thromboinflammatory responses. These advances have opened new opportunities to therapeutically target thrombosis at the intersection of metabolism and inflammation.