The Italian debate on the so-called ‘inner areas’ has received a much-needed boost, following the COVID-19 pandemic, which has further highlighted the differences between metropolitan and inner areas. While the progressive depopulation of inner areas is a worrying phenomenon, the limits of incessant urbanisation and the concentration of settlement and infrastructure policies in large conurbations have become evident. Departing from the framework of the B4R-Branding4Resilience research project of national interest and, by continuing in the furrow initiated by the SNAI, but also surpassing it, the aim of the University of Palermo’s research is to define the requirement for a more inclusive settlement model in the Sicani area in Sicily (Italy) to re-balance existing asymmetries by recharging peripheral areas with new centrality. The aims of the research are to demonstrate that inner areas could be an engine for innovation, thereby outlining a roadmap through which to encourage the resilience of new sustainable lifestyles. These aims would be achieved by working on new perspectives and projects, which are capable of radically modifying production, consumption, and tourism dynamics and work/life models, and which are gleaned from a study regarding the Sicani area in Sicily. The paper discusses case study quantitative and qualitative analyses and first results.