Antonio Macchiarulo is Full Professor of Medicinal Chemistry at the Department of Pharmaceutical Sciences of the University of Perugia (Italy) – Department of Excellence 2018/2022. He received his PhD in Chemistry and Technology of Drugs in 2004, and was awarded with a Marie Curie fellowship (European Commission Program ‘Quality of Life,’ contract number: QLRI-1999-50595) at the European Bioinformatics Institute in Cambridge (UK), where he worked on the specificity of substrate recognition by enzymes. In 2010, he co-founded TES Pharma Srl, a biotech company aimed at the development of innovative drugs to treat metabolic disorders and cancer. From to 2016 to 2021, Antonio Macchiarulo has been member of the Scientific Committee of the European School of Medicinal Chemistry (ESMEC). Research activities of Antonio Macchiarulo cover the application and integration of computational biology, computational modelling, computer aided design, biomodelling, medicinal chemistry and biophysics to understand more about how proteins (including drug targets) works at the molecular level, how these molecules recognize one another and their cognate ligands (including drugs), and how the selectivity and/or specificity of such interactions are affected by mutations in cancer patients to generate poor therapy response and/or resistance. Much of these research activities are collaborative, involving either national and international experimental research groups.