Chitin is the second most abundant biopolymer consisting of N-acetylglucosamine units and is primarily derived from the shells of marine crustaceans and the cell walls of organisms (such as bacteria, fungi, and algae). Being a biopolymer, its materialistic properties, such as biodegradability, and biocompatibility, make it a suitable choice for biomedical applications. Similarly, its deacetylated derivative, chitosan, exhibits similar biocompatibility and biodegradability properties, making it a suitable support material for biomedical applications. Furthermore, it has intrinsic material properties such as antioxidant, antibacterial, and antitumor. Population studies have projected nearly 12 million cancer patients across the globe, where most will be suffering from solid tumors. One of the shortcomings of potent anticancer drugs is finding a suitable cellular delivery material or system. Therefore, identifying new drug carriers to achieve effective anticancer therapy is becoming essential. This paper focuses on the strategies implemented using chitin and chitosan biopolymers in drug delivery for cancer treatment.

Chitosan is the most suitable encapsulation polymer because of its natural abundance, biodegradability, and surface functional groups in the form of free NH₂ groups. The presence of NH₂ groups allows for the facile grafting of functionalized molecules onto the chitosan surface, resulting in multifunctional materialistic applications. Quaternization of chitosan’s free amino is one of the typical chemical modifications commonly achieved under acidic conditions. This quaternization improves its ionic character, making it ready for ionic–ionic surface modification. Although the cationic nature of chitosan alone exhibits antibacterial activity because of its interaction with negatively-charged bacterial membranes, the nanoscale size of chitosan further amplifies its antibiofilm activity. Additionally, the researcher used chitosan nanoparticles as polymeric materials to encapsulate antibiofilm agents (such as antibiotics and natural phytochemicals), serving as an excellent strategy to combat biofilm-based secondary infections. This paper provided a summary of available carbohydrate-based biopolymers as antibiofilm materials. Furthermore, the paper focuses on chitosan nanoparticle-based encapsulation of basil essential oil (Ocimum basilicum), mandarin essential oil (Citrus reticulata), Carum copticum essential oil (“Ajwain”), dill plant seed essential oil (Anethum graveolens), peppermint oil (Mentha piperita), green tea oil (Camellia sinensis), cardamom essential oil, clove essential oil (Eugenia caryophyllata), cumin seed essential oil (Cuminum cyminum), lemongrass essential oil (Cymbopogon commutatus), summer savory essential oil (Satureja hortensis), thyme essential oil, cinnamomum essential oil (Cinnamomum zeylanicum), and nettle essential oil (Urtica dioica). Additionally, chitosan nanoparticles are used for the encapsulation of the major essential components carvacrol and cinnamaldehyde, the encapsulation of an oil-in-water nanoemulsion of eucalyptus oil (Eucalyptus globulus), the encapsulation of a mandarin essential oil nanoemulsion, and the electrospinning nanofiber of collagen hydrolysate–chitosan with lemon balm (Melissa officinalis) and dill (Anethum graveolens) essential oil.

Synthetic and natural fibers are widely used in the textile industry. Natural fibers include cellulose-based materials like cotton, and regenerated fibers like viscose as well as protein-based fibers such as silk and wool. Synthetic fibers, on the other hand, include PET and polyamides (like nylon). Due to significant differences in their chemistry, distinct dyeing processes are required, each generating specific waste. For example, cellulose fibers exhibit chemical inertness toward dyes, necessitating chemical auxiliaries that contribute to wastewater contamination, whereas synthetic fibers are a major source of non-biodegradable microplastic emissions. Addressing the environmental impact of fiber processing requires a deep molecular-level understanding to enable informed decision-making. This manuscript emphasizes potential solutions, particularly through the biodegradation of textile materials and related chemical waste, aligning with the United Nations Sustainable Development Goal 6, which promotes clean water and sanitation. For instance, cost-effective methods using enzymes or microbes can aid in processing the fibers and their associated dyeing solutions while also addressing textile wastewater, which contains high concentrations of unreacted dyes, salts, and other highly water-soluble pollutants. This paper covers different aspects of fiber chemistry, dyeing, degradation mechanisms, and the chemical waste produced by the textile industry, while highlighting microbial-based strategies for waste mitigation. The integration of microbes not only offers a solution for managing large volumes of textile waste but also paves the way for sustainable technologies.

Innate inflammation beyond a threshold is a significant problem involved in cardiovascular diseases, cancer, and many other chronic conditions. Cyclo­oxygenase (COX) enzymes are key inflammatory markers as they catalyze prostaglandins production and are crucial for inflammation processes. While COX-I is constitutively expressed and is generally involved in “housekeeping” roles, the expression of the COX-II isoform is induced by the stimulation of different inflammatory cytokines and also promotes the further generation of pro-inflammatory cytokines and chemokines, which affect the prognosis of various diseases. Hence, COX-II is considered an important therapeutic target for drug development against inflammation-related illnesses. Several selective COX-II inhibitors with safe gastric safety profiles features that do not cause gastrointestinal complications associated with classic anti-inflammatory drugs have been developed. Nevertheless, there is mounting evidence of cardiovascular side effects from COX-II inhibitors that resulted in the withdrawal of market-approved anti-COX-II drugs. This necessitates the development of COX-II inhibitors that not only exhibit inhibit potency but also are free of side effects. Probing the scaffold diversity of known inhibitors is vital to achieving this goal. A systematic review and discussion on the scaffold diversity of COX inhibitors are still limited. To address this gap, herein we present an overview of chemical structures and inhibitory activity of different scaffolds of known COX-II inhibitors. The insights from this article could be helpful in seeding the development of next-generation COX-II inhibitors.

MiRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has been reported as a hallmark of cancer progression, acting as an independent prediction marker for an individual cancer patient. The interplay of miRNA and lncRNA decides the variation of tumorigenesis that could be mediated by acting as sponges for endogenous RNAs, regulating miRNA decay, mediating intra-chromosomal interactions, and modulating epigenetic components. This paper focuses on the influence of crosstalk between lncRNA and miRNA on cancer hallmarks such as epithelial-mesenchymal transition, hijacking cell death, metastasis, and invasion. Other cellular roles of crosstalks, such as neovascularization, vascular mimicry, and angiogenesis were also discussed. Additionally, we reviewed crosstalk mechanism with specific host immune responses and targeting interplay (between lncRNA and miRNA) in cancer diagnosis and management. Graphic Abstract

Natural dyes and pigments are gaining importance as a sustainable alternative to synthetic dyes. Sourced from renewable materials, they are known for their biodegradable and non-toxic properties, offering a diverse range of color profiles and applications across industries such as textiles, cosmetics, food, and pharmaceuticals. This manuscript discusses various aspects of natural dyes and pigments (derived from plants and microbes), including anthocyanins, flavonoids, carotenoids, lactones, and chlorophyll. Furthermore, it highlights the polyphenolic nature of these compounds, which is responsible for their antioxidant activity and contributes to their anticancer, antibacterial, antifungal, antiprotozoal, and immunomodulatory effects. However, natural dyes are often categorized as pigments rather than dyes due to their limited solubility, a consequence of their molecular characteristics. Consequently, this manuscript provides a detailed discussion of key structural challenges associated with natural dyes and pigments, including thermal decomposition, photodegradation, photoisomerization, cross-reactivity, and pH sensitivity. Due to these limitations, natural dyes are currently used in relatively limited applications, primarily in the food industry, and, to lesser extent, in textiles and coatings. Nevertheless, with ongoing research and technological innovations, natural dyes present a viable alternative to synthetic dyes, promoting a more sustainable and environmentally conscious future.