Ángel Serrano Alarcón

Mr. Ángel Serrano Alarcón

Reutlingen University
orcid

Research Focus & Metrics

Academic Career Length

7Years (2020-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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10 July 2023 in Biomedical Engineering Letters
Verified
Journal Article
Open access
PDF file
Maksym GaidukMaksym Gaiduk
Maksym Gaiduk
ÁAÁngel Serrano Alarcón
Ángel Serrano Alarcón
Ralf SeepoldRalf Seepold
Ralf Seepold
Natividad Martínez MadridNatividad Martínez Madrid
Natividad Martínez Madrid
The scoring of sleep stages is one of the essential tasks in sleep analysis. Since a manual procedure requires considerable human and financial resources, and incorporates some subjectivity, an automated approach could result in several advantages. There have been many developments in this area, and in order to provide a comprehensive overview, it is essential to review relevant recent works and summarise the characteristics of the approaches, which is the main aim of this article. To achieve it, we examined articles published between 2018 and 2022 that dealt with the automated scoring of sleep stages. In the final selection for in-depth analysis, 125 articles were included after reviewing a total of 515 publications. The results revealed that automatic scoring demonstrates good quality (with Cohen's kappa up to over 0.80 and accuracy up to over 90%) in analysing EEG/EEG + EOG + EMG signals. At the same time, it should be noted that there has been no breakthrough in the quality of results using these signals in recent years. Systems involving other signals that could potentially be acquired more conveniently for the user (e.g. respiratory, cardiac or movement signals) remain more challenging in the implementation with a high level of reliability but have considerable innovation capability. In general, automatic sleep stage scoring has excellent potential to assist medical professionals while providing an objective assessment.

14 July 2023 in Frontiers in Neuroscience
Verified
Journal Article
Open access
ÁAÁngel Serrano Alarcón
Ángel Serrano Alarcón
NMNatividad Martínez Madrid
Natividad Martínez Madrid
RSRalf Seepold
Ralf Seepold
JOJuan Antonio Ortega
Juan Antonio Ortega
Background: Polysomnography (PSG) is the gold standard for detecting obstructive sleep apnea (OSA). However, this technique has many disadvantages when using it outside the hospital or for daily use. Portable monitors (PMs) aim to streamline the OSA detection process through deep learning (DL).Materials and methods: We studied how to detect OSA events and calculate the apnea-hypopnea index (AHI) by using deep learning models that aim to be implemented on PMs. Several deep learning models are presented after being trained on polysomnography data from the National Sleep Research Resource (NSRR) repository. The best hyperparameters for the DL architecture are presented. In addition, emphasis is focused on model explainability techniques, concretely on Gradient-weighted Class Activation Mapping (Grad-CAM).Results: The results for the best DL model are presented and analyzed. The interpretability of the DL model is also analyzed by studying the regions of the signals that are most relevant for the model to make the decision. The model that yields the best result is a one-dimensional convolutional neural network (1D-CNN) with 84.3% accuracy.Conclusion: The use of PMs using machine learning techniques for detecting OSA events still has a long way to go. However, our method for developing explainable DL models demonstrates that PMs appear to be a promising alternative to PSG in the future for the detection of obstructive apnea events and the automatic calculation of AHI.

17 November 2021 in Life
Verified
Journal Article
Open access
PDF file
ÁAÁngel Serrano Alarcón
Ángel Serrano Alarcón
Natividad Martínez MadridNatividad Martínez Madrid
Natividad Martínez Madrid
Ralf SeepoldRalf Seepold
Ralf Seepold
Introduction. Despite its high accuracy, polysomnography (PSG) has several drawbacks for diagnosing obstructive sleep apnea (OSA). Consequently, multiple portable monitors (PMs) have been proposed. Objective. This systematic review aims to investigate the current literature to analyze the sets of physiological parameters captured by a PM to select the minimum number of such physiological signals while maintaining accurate results in OSA detection. Methods. Inclusion and exclusion criteria for the selection of publications were established prior to the search. The evaluation of the publications was made based on one central question and several specific questions. Results. The abilities to detect hypopneas, sleep time, or awakenings were some of the features studied to investigate the full functionality of the PMs to select the most relevant set of physiological signals. Based on the physiological parameters collected (one to six), the PMs were classified into sets according to the level of evidence. The advantages and the disadvantages of each possible set of signals were explained by answering the research questions proposed in the methods. Conclusions. The minimum number of physiological signals detected by PMs for the detection of OSA depends mainly on the purpose and context of the sleep study. The set of three physiological signals showed the best results in the detection of OSA.

1 October 2022
Verified
Book Chapter
Closed access
PDF file
ÁAÁngel Serrano Alarcón
Ángel Serrano Alarcón
Natividad Martínez MadridNatividad Martínez Madrid
Natividad Martínez Madrid
Ralf SeepoldRalf Seepold
Ralf Seepold
Juan A. OrtegaJuan A. Ortega
Juan A. Ortega

1 January 2020 in Procedia Computer Science
Verified
Journal Article
Open access
YSYurii Shkilniuk
Yurii Shkilniuk
ÁAÁngel Serrano Alarcón
Ángel Serrano Alarcón
Maksym GaidukMaksym Gaiduk
Maksym Gaiduk
Ralf SeepoldRalf Seepold
Ralf Seepold
Natividad Martínez MadridNatividad Martínez Madrid
Natividad Martínez Madrid

14 December 2025 in Journal of Sleep Research
Verified
Journal Article
Open access
ÁAÁngel Serrano Alarcón
Ángel Serrano Alarcón
MGMaksym Gaiduk
Maksym Gaiduk
NMNatividad Martínez Madrid
Natividad Martínez Madrid
JOJuan Antonio Ortega
Juan Antonio Ortega
Ralf SeepoldRalf Seepold
Ralf Seepold
Automatic sleep stage classification is essential for enabling non‐invasive, at‐home monitoring. However, current methods often rely on electroencephalogram (EEG) signals and ad‐hoc development approaches that limit reproducibility. We present a reproducible engineering framework for a deep learning model based on the U‐Net architecture that classifies sleep into five stages (Wake, N1, N2, N3 and REM) or four (Wake, Light Sleep, Deep Sleep and REM) using only three easily acquired physiological signals: oxygen saturation (SpO), heart rate (HR) and abdominal respiratory effort (AbdRes). In contrast to most previous studies, our model provides sleep stage predictions on a per‐second basis, thus overcoming the limitations associated with fixed 30‐s epochs. The model was trained on the Sleep Heart Health Study—Visit 2 (SHHS2) dataset and externally validated on the Multi‐Ethnic Study of Atherosclerosis (MESA). Optimisation of the model was achieved via Keras Tuner with the Hyperband algorithm. The study achieved weighted F1‐scores of 68% (five‐stage) and 71% (four‐stage) with Cohen's Kappa of 0.61 and 0.67 on SHHS2, with consistent performance on MESA. These results demonstrate strong generalisation and suggest that this lightweight, EEG‐free approach offers a practical path towards scalable, clinically relevant sleep monitoring.