It is notable that indoor environment quality plays a crucial role in guaranteeing health, especially if we consider that people spend more than 90% of their time indoors, a percentage that increases for people on low income. This role assumes even further significance when dealing with distressed urban areas, vulnerable areas within cities that suffer from multiple deprivations. The community-based interdisciplinary research-action group of the University La Sapienza focused on a complex in the outskirts of Rome. The aim was to assess the correlations between architectural aspects of the indoor environment, socio-economic conditions, such as lifestyles and housing conditions, and eventually health outcomes. The intent of providing a comparative methodology in a context where official data is hard to find, led to the integration of social, health, and housing questionnaires with various environmental software simulations. What emerged is that underprivileged housing conditions, characterized by mold, humidity, unhealthiness, thermohygrometric discomfort, architectural barriers, and overcrowding, are often associated with recurrent pathologies linked to arthritis, respiratory diseases, and domestic accidents.

The study reports an urban health investigation conducted in Bastogi, an outskirt of Rome (Italy) characterised by social marginalization and deprivation. Our aim was to analyse the health perception, health-related behaviours, and interaction with healthcare professionals of the inhabitants of Bastogi compared to the population living in the area of the same local health unit (ASL). The Progresses of Health Authorities for Health in Italy questionnaire (PASSI) was administered to a sample of 210 inhabitants of Bastogi. Data were analysed and compared to those of the ASL collected in 2017–2018. The socio-economic indicators showed an overall worse condition for the inhabitants of Bastogi, with a significantly higher proportion of foreign and unemployed residents and a lower educational level compared to the ASL. Significant differences in the prevalence of non-communicable diseases, mental health complaints, and participation in prevention strategies, including cancer screening, were found. The questionnaire showed a lower help-seeking behaviour and a lack of reliance on health professionals in Bastogi inhabitants. Our findings highlight how social determinants produce health inequities and barriers to accessing healthcare. The difficulties of conducting quantitative research in complex and hard-to-reach contexts, characterized by high social vulnerability, are outlined.