Background: Guidelines generally recommend achieving a biochemically euthyroid state before thyroidectomy in patients with an indication for surgery to reduce the risk of thyroid storm. However, in real-world settings, this may not always be feasible. This study aimed to compare perioperative outcomes between biochemically controlled (normal fT3 and fT4) and uncontrolled (elevated fT3 and/or fT4) hyperthyroid patients undergoing thyroidectomy. Methods: We retrospectively analyzed patients who underwent thyroidectomy for hyperthyroidism at our institution between September 2020 and 2024. The demographic, perioperative, and postoperative data were collected. Patients with preoperative fT3 and/or fT4 levels above the institutional reference range were classified as uncontrolled, whereas those with both fT3 and fT4 levels within the reference range were considered controlled. The outcomes were compared between the controlled and uncontrolled groups. Results: A total of 110 patients were included: 92 (83.6%) in the controlled group and 18 (16.4%) in the uncontrolled group. Patients in the uncontrolled group were significantly younger (median age 33.5 vs. 49 years, p = 0.015). Graves’ disease was more prevalent among uncontrolled patients (83.3% vs. 45.7%, p = 0.013). The use of Lugol’s iodine (27.8% vs. 1.1%, p < 0.001) and steroids (38.9% vs. 6.5%, p < 0.001) was significantly higher in the uncontrolled group than in the control group. Operative times and complication rates—including transient/permanent hypocalcemia, recurrent laryngeal nerve palsy, and neck hematoma—did not significantly differ between the groups. Conclusions: Despite the presence of biochemical hyperthyroidism, no thyroid storm occurred in our cohort, and complication rates were comparable between groups. These findings suggest that thyroidectomy may be performed in selected patients without full biochemical control, particularly in urgent situations or in high-volume centers with experienced surgical teams. However, biochemical euthyroidism remains the standard of care, and our results should be interpreted cautiously given the small sample size and single-center setting.

Introduction: This retrospective study compares the outcomes of right hemicolectomy (RHC) and extended right hemicolectomy (ERHC) in patients with hepatic flexure and proximal transverse colon tumors. Methods: Data from 85 patients who underwent surgery for colonic adenocarcinoma between January 2015 and December 2023 were analyzed retrospectively. Patients who had hepatic flexure and proximal transverse colon tumors were included in the analysis. Patients were divided into two groups: RHC and ERHC. The primary endpoints were overall survival (OS) and disease-free survival (DFS), with secondary outcomes including postoperative complications and pathological data. Results: The RHC group comprised 46 patients, while the EHRC group had 39 patients. The study found no significant difference in 5-year OS (77% RHC vs 69% ERHC, P = 0.135) or 5-year DFS (87% RHC vs 81% ERHC, P = 0.388) between the two groups. Although the ERHC group had a higher number of harvested lymph nodes (27 vs 22, P = 0.022), this did not correlate with improved survival outcomes. Tumor localization was identified as a significant factor influencing OS, with hepatic flexure tumors showing better survival compared to proximal transverse colon tumors. No significant differences were observed between the groups regarding postoperative complications. Conclusion: Our study suggests that while ERHC leads to a higher lymph node yield, it does not significantly improve survival outcomes compared to RHC in patients with hepatic flexure and proximal transverse colon tumors. Further research is needed to optimize surgical strategies and improve patient outcomes.