Background and Aims: Coronary artery disease (CAD), a leading cause of death globally, is among the most commonly diagnosed manifestations of heart disease. Although invasive coronary angiography (ICA) remains the “gold standard” to detect CAD, it is accompanied by several limitations. This review aims to present recent Noninvasive diagnostic modalities in CAD, report and compare the diagnostic accuracy of different invasive and noninvasive tests in CAD, and analyze both the current and future clinical implications of noninvasive modalities that regularly evaluate CAD in modern cardiology.Methods: Given this background and purpose, various, reliable online sources were searched to find relevant data for our narrative review. To this end, several databases were consulted including Google Scholar, PubMed, and Embase.Results: The weight of the evidence highlights that the accuracy of several noninvasive diagnostic modalities in CAD is high and the choice of the most suitable noninvasive diagnostic testing mainly depends on local resources, tests' features, and patients' characteristics, which determine the pretest probability of CAD. For patients presenting an intermediate pretest probability of the disease noninvasive testing seems to be appropriate.Conclusion: Noninvasive diagnostic modalities could limit the usage of invasive modalities in CAD. Nowadays, noninvasive diagnostic modalities are increasingly being promoted as they provide useful and reliable information about the various aspects of CAD. Undoubtedly, more efforts are needed to optimize noninvasive diagnostic tests to demonstrate their full potential in CAD.