The pandemic outbreaks such as severe acute respiratory syndrome, swine flu, Middle East respiratory syndrome, Ebola, zika virus outbreak, and coronavirus are influential events that were transmitted through various countries in a short period. Due to sudden outbreaks of this pandemic and unavailability of rapid diagnostic kits, strategic management, and treatment caused a high rate of mortality and mortality. Primarily diagnosis and detection of infections are performed through tedious pathological tests; however, the recent advancements in nanotechnology-based robust sensors are handy and rapid to detect such infections. Smart biosensors offer promising prospects such as portability, flexibility, multifunctional use, and efficient operation that provides fast and real-time response against tested components. The biosensors act as an interface between biological analytes and quantifiable electrical signals. Enabling this biosensor with nanotechnology has not only revolutionized the diagnosis of infection but also regular health checkups. The present review presents compressive updates on different types of sensors available to measure health conditions, with elaboration enabling sensor processing using nanotechnology. Moreover, the safety consideration and applicability of wearable sensors in day-to-day routine activity.