Grace Kim

Grace Kim

Auto-generated profile, based on publicly available information

Grace Kim

Department of Pediatrics, Yale University School of Medicine, New Haven, CT

Research Focus & Metrics

Explore full metrics on Scilit

Academic Career Length

16Years (2011-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
22 November 2011 in Hepatology
Verified
Journal Article
Open access
PDF file
NSNicola Santoro
Nicola Santoro
CZClarence K. Zhang
Clarence K. Zhang
HZHongyu Zhao
Hongyu Zhao
APAndrew J. Pakstis
Andrew J. Pakstis
GKGrace Kim
Grace Kim
SCSonia Caprio
Sonia Caprio
Recently, the single nucleotide polymorphism (SNP) identified as rs1260326, in the glucokinase regulatory protein ( GCKR ), was associated with hypertriglyceridemia in adults. Because accumulation of triglycerides in hepatocytes represents the hallmark of steatosis, we aimed to investigate whether this variant might be associated with fatty liver (hepatic fat content, HFF%). Moreover, because recently rs738409 in the PNPLA3 and rs2854116 in the APOC3 were associated with fatty liver, we explored how the GCKR SNP and these two variants jointly influence hepatosteatosis. We studied 455 obese children and adolescents (181 Caucasians, 139 African Americans, and 135 Hispanics). All underwent an oral glucose tolerance test and fasting lipoprotein subclasses measurement by proton nuclear magnetic resonance. A subset of 142 children underwent a fast gradient magnetic resonance imaging to measure the HFF%. The rs1260326 was associated with elevated triglycerides (Caucasians P = 0.00014; African Americans P = 0.00417), large very low-density lipoprotein (VLDL) (Caucasians P = 0.001; African Americans, P = 0.03), and with fatty liver (Caucasians P = 0.034; African Americans P = 0.00002; and Hispanics P = 0.016). The PNPLA3 , but not the APOC3 rs2854116 SNP, was associated with fatty liver but not with triglyceride levels. There was a joint effect between the PNPLA3 and GCKR SNPs, explaining 32% of HFF% variance in Caucasians ( P = 0.00161), 39.0% in African Americans ( P = 0.00000496), and 15% in Hispanics ( P = 0.00342). Conclusion : The rs1260326 in GCKR is associated with hepatic fat accumulation along with large VLDL and triglyceride levels. GCKR and PNPLA3 act together to convey susceptibility to fatty liver in obese youths.