The method of synthesis of Atomoxetine is developed, including enzyme-catalyzed stereospecific reduction 3-chloro-1-phenyl-propan-1-one and Mitsunobu condensation with a chiral alcohol, and o-cresol. New potential human carbonic anhydrase inhibitors were obtained via reaction Atomoxetine with carboxylic derivatives of benzene and thiophene containing primary sulfonamide moiety.