Colour tunable TADF emitters with strong AIE characteristics exhibited EQEs above 20%.

Introduction: Intravenous (i.v.) paracetamol is considered as an effective and safe analgesic agent in labouring women, but its effect on patients already receiving epidural analgesia is not well documented. Aim: To know whether i.v. paracetamol reduces epidural local anaesthetic opioid combination consumption in labour by virtue of its analgesic effects. Materials and Methods: The present double blind, randomised clinical study was conducted on 88 singleton term pregnant women in active labour. Half of these women (n=44, Group P) received 1000 mg (100 mL) i.v. paracetamol and rest (n=44, Group C) received 100 mL normal saline as placebo (n=44). Thirty minutes later all women received 10 mL of ropivacaine 0.125% with 2 μg/mL fentanyl through epidural catheter, followed by continuous background epidural infusion of 5 mL/h with a provision of patient controlled bolus 5 mL of same drug with a lock-out interval of 15 minutes. The primary outcome was hourly mean consumption of epidural drug in mL. Results: The hourly mean drug consumption in the paracetamol group was significantly lower as compared to control group (7.75±0.93 mL/hr vs. 8.23±0.99 mL/hr; p=0.022). The mean number of boluses needed by parturient were also significantly less in the paracetamol group (0.58±0.66 vs. 1.02±0.82; p=0.005). Pain relief after epidural placement was adequate in both groups with similar Visual Analogue Scale (VAS) values without significant intergroup differences. Conclusion: It can be concluded that 1000 mg i.v. paracetamol is a safe and effective adjunct to Patient Controlled Epidural Analgesia (PCEA).

Quinoline is one of the most widely studied scaffold due to its high biological activities like antimalarial, antitubercular, antitumor, anti-inflammatory, antifungal, antiprotozoal, etc. this compound also has corrosion resistant, fluorescent properties, which make it industrially also important. There are various conventional methods to synthesize this scaffold, but these have several drawbacks like harsh conditions, susceptible functional group get affected. These drawbacks can be overcome by the use of green methods. These methods include Tandem/domino methods, cascade synthesis, cyclization/annulation by C-C, C-N bond formation, use of microwave, ultrasonication, ionic liquids, recyclable nano-catalyst, solid phase synthesis, solvent free synthesis, water as solvent, ball milling, use of cheap, easily available metal catalyst etc. Nowadays various naturally occurring biomass as raw material are also utilized as one of the reactant. These green methods reduce hazards to human as well as environment. This review provides an overview of recent discoveries in green synthetic methods of quinoline scaffold, and various applications of quinoline scaffold in medicine and other industrial applications.