Alzheimers disease (AD) is a brain illness that affects learning and memory capacities over time. In recent investigations, acupuncture has been shown to be an effective alternative treatment for AD. We investigated the effect of acupuncture on learning and memory abilities using a water maze in APP/PS1 transgenic mice. The amounts of Aβ and tau protein in mices hippocampal tissue were determined using Western blot. The levels of IL-1β, IL-10, LPS and TNF-α in mices serum were measured using ELISA. The variations of gut microbiota in mices feces were determined using the 16SrDNA technique, and the metabolites were examined using a untargeted metabolomics methodology. The results showed that acupuncture treatment improved mices learning and memory abilities substantially. Acupuncture therapy regulated the Aβ and tau protein concentration as well as the levels of IL-10 and LPS. Acupuncture treatment influenced the mouse microbiota and metabolites and had been linked to six biochemical pathways. This study adds to our understanding of the effect of acupuncture on AD and opens the door to further research into the alterations of intestinal bacteria in the presence of AD.

Our study revealed that the children’s microbiota was partially transmitted from their family members and specific putative transmissible ASVs were associated with the immune system of children. These findings suggest that home life plays a key role in the shaping of young children’s microbiomes and has long-term health benefits.

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Zinc dialkyldithiophosphates (ZDDPs) provide efficient and effective anti-wear, anti-oxidation and anti-corrosion properties in engine oil formulations. Two kinds of formulated engine oils were investigated including Oil 1 containing secondary ZDDPs, and Oil 2 containing primary/secondary ZDDPs. It revealed that different types of ZDDPs exhibits different volatilities and have different effects in the Sequence IIIG test. ZDDPs with higher molecular weight alcohols exhibit a relatively low volatility. The combination of primary/secondary ZDDPs exhibits higher phosphorus volatility in the Sequence IIIG, but have the same anti-wear protective behavior than that of the secondary ZDDPs in field tests. The field test results of phosphorus volatility and viscosity increase show encouraging agreement with the results of the Sequence IIIG test. However, the field test exhibits lower phosphorus volatility than the Sequence IIIG engine test. Results of used oil analyses showed that the wear elements, viscosity, TAN increase and TBN retention were in acceptable limits at the end of the field test.