In recent decades, the demand for computational power has surged, particularly with the rapid expansion of artificial intelligence (AI). As we navigate the post-Moore's law era, the limitations of traditional electrical digital computing, including process bottlenecks and power consumption issues, are propelling the search for alternative computing paradigms. Among various emerging technologies, integrated photonics stands out as a promising solution for next-generation high-performance computing, thanks to the inherent advantages of light, such as low latency, high bandwidth, and unique multiplexing techniques. Furthermore, the progress in photonic integrated circuits (PICs), which are equipped with abundant photoelectronic components, positions photonic-electronic integrated circuits as a viable solution for high-performance computing and hardware AI accelerators. In this review, we survey recent advancements in both PIC-based digital and analog computing for AI, exploring the principal benefits and obstacles of implementation. Additionally, we propose a comprehensive analysis of photonic AI from the perspectives of hardware implementation, accelerator architecture, and software-hardware co-design. In the end, acknowledging the existing challenges, we underscore potential strategies for overcoming these issues and offer insights into the future drivers for optical computing.

We demonstrate a label-free, high-throughput cell separation method via a SSAW-based acoustofluidic device with a serpentine channel for clinical diagnosis and point-of-care analysis.

In the context of continued spread of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 and the emergence of new variants, the demand for rapid, accurate, and frequent detection is increasing. Moreover, the new predominant strain, Omicron variant, manifests more similar clinical features to those of other common respiratory infections. The concurrent detection of multiple potential pathogens helps distinguish SARS-CoV-2 infection from other diseases with overlapping symptoms, which is significant for providing tailored treatment to patients and containing the outbreak. Here, we report a lab-on-a-chip biosensing platform for SARS-CoV-2 detection based on the subwavelength grating micro-ring resonator. The sensing surface is functionalized by specific antibody against SARS-CoV-2 spike protein, which could produce redshifts of resonant peaks by antigen–antibody combination, thus achieving quantitative detection. Additionally, the sensor chip is integrated with a microfluidic chip featuring an anti-backflow Y-shaped structure that enables the concurrent detection of two analytes. In this study, we realized the detection and differentiation of COVID-19 and influenza A H1N1. Experimental results indicate that the limit of detection of our device reaches 100 fg/ml (1.31 fM) within 15 min detecting time, and cross-reactivity tests manifest the specificity of the optical diagnostic assay. Furthermore, the integrated packaging and streamlined workflow facilitate its use for clinical applications. Thus, the biosensing platform presents a promising approach for attaining highly sensitive, selective, multiplexed, and quantitative point-of-care diagnosis and distinction between COVID-19 and influenza.

As photonic technologies grow in multidimensional aspects, integrated photonics holds a unique position and continuously presents enormous possibilities for research communities. Applications include data centers, environmental monitoring, medical diagnosis, and highly compact communication components, with further possibilities continuously growing. Herein, we review state-of-the-art integrated photonic on-chip sensors that operate in the visible to mid-infrared wavelength region on various material platforms. Among the different materials, architectures, and technologies leading the way for on-chip sensors, we discuss the optical sensing principles that are commonly applied to biochemical and gas sensing. Our focus is on passive optical waveguides, including dispersion-engineered metamaterial-based structures, which are essential for enhancing the interaction between light and analytes in chip-scale sensors. We harness a diverse array of cutting-edge sensing technologies, heralding a revolutionary on-chip sensing paradigm. Our arsenal includes refractive-index-based sensing, plasmonics, and spectroscopy, which forge an unparalleled foundation for innovation and precision. Furthermore, we include a brief discussion of recent trends and computational concepts, incorporating Artificial Intelligence & Machine Learning (AI/ML) and deep learning approaches over the past few years to improve the qualitative and quantitative analysis of sensor measurements.

The rapid growth in computing demands, particularly driven by artificial intelligence applications, has begun to exceed the capabilities of traditional electronic hardware. Optical computing offers a promising alternative due to its parallelism, high computational speed, and low power consumption. However, existing photonic integrated circuits are constrained by large footprints, costly electro-optical interfaces, and complex control mechanisms, limiting the practical scalability of optical neural networks (ONNs). To address these limitations, we introduce a block-circulant photonic tensor core for a structure-compressed optical neural network (StrC-ONN) architecture. The structured compression technique substantially reduces both model complexity and hardware resources without sacrificing the versatility of neural networks, and achieves accuracy comparable to uncompressed models. Additionally, we propose a hardware-aware training framework to compensate for on-chip nonidealities to improve model robustness and accuracy. Experimental validation through image processing and classification tasks demonstrates that our StrC-ONN achieves a reduction in trainable parameters of up to 74.91%, while still maintaining competitive accuracy levels. Performance analyses further indicate that this hardware–software co-design approach is expected to yield a 3.56× improvement in power efficiency. By reducing both hardware requirements and control complexity across multiple dimensions, this work explores a pathway toward practical and scalable ONNs, highlighting a promising route to address future computational efficiency challenges.

Pancreatic cancer remains one of the deadliest cancers due to the lack of effective early detection tools. While deep neural networks (DNNs) have shown promise in tumor segmentation, electronic accelerators suffer from power inefficiency and latency. To address this, we propose MediONN—a photonic neural network system implemented on an integrated chip, optimized for 3D medical image segmentation. MediONN integrates a 4×4 photonic neural processor within a hierarchical 3D optical computation framework. To improve training convergence, we introduce a segmentation-specific Gaussian weight initialization strategy, along with 3D optical convolutional layers for volumetric feature extraction. Unlike prior photonic systems focused on classification, MediONN is the first to demonstrate optical neural networks (ONNs) directly applied to 3D segmentation. On the NIH pancreas CT dataset, MediONN achieves a Dice similarity coefficient (DSC) of 0.5215 (2D) and 0.5302 (3D), with peak DSCs of 0.5919 (2D) and 0.8788 (3D). Comprehensive evaluation metrics confirm MediONN’s segmentation accuracy is comparable to electronic counterparts, while offering significant gains in computational speed and energy efficiency. These results highlight the scalability and biomedical potential of integrated photonic ONNs.