In the state of Sonora, the bite of the spiders Latrodectus mactans, Latrodectus geometricus and Latrodectus hesperus, can cause serious health complications due to their toxicity. To characterize the conditions under which poisonings by Latrodectus spider bites occurred. Retrospective descriptive study of confirmed cases of poisoning by Latrodectus spider bites that occurred in municipalities of Sonora from 2021 to 2024. 65 cases of Latrodectus bites were obtained (52.3% men, 47.7% women). The 78.5% of the cases occurred in the home and 44.6% were recorded in bedrooms, the right lower limb was the most frequent anatomical area for bites (32.3%). Of the recorded cases, 98.5% presented some degree of poisoning and 1.5% were asymptomatic. The most frequent symptoms were intense pain (87.5%), itching (54.7%), and local edema (50.0%). The 68.8% of the poisoned individuals required one bottle of faboterápico for treatment. Latrodectus bites occurred mostly in men, primarily in bedrooms at home while they were resting. The lesions were located primarily on the right lower and upper limbs (63.1%), and during the study period, 84.6% of the 65 reported cases received treatment, with no deaths reported.