A 10,000-year transect of Roman populations: Rome wasn't built (or settled) in a day. Antonio et al. performed an ancestral DNA analysis to investigate the genetic changes that occurred in Rome and central Italy from the Mesolithic into modern times. By examining 127 Roman genomes and their archaeological context, the authors demonstrate a major ancestry shift in the Neolithic between hunter gatherers and farmers. A second ancestry shift is observed in the Bronze Age, likely coinciding with trade and an increased movement of populations. Genetic changes track the historical changes occurring in Rome and reflect gene flow from across the Mediterranean, Europe, and North Africa over time. Science , this issue p. 708

Significance: The extent to which Neanderthals differ from us is the focus of many studies in human evolution. There is debate about their pace of growth and early-life metabolic constraints, both of which are still poorly understood. Here we use chemical and isotopic patterns in tandem with enamel growth rates of three Neanderthal milk teeth from northeastern Italy to explore the early life of these individuals. Our study shows that these Neanderthals started to wean children at 5 to 6 months, akin to modern humans, implying similar energy demands during early infancy. Dental growth rates confirm this and follow trajectories comparable with modern humans. Contrary to previous evidence, we suggest that differences in weaning age did not contribute to Neanderthals’ demise.

The reconstruction of ancient diets by means of stable isotopes analyses acquires a deeper meaning when their results are compared with other odonto-skeletal indicators which are strongly contextualized in the light of historical and archaeological evidence. Nevertheless, the outcomes can be contradictory or, more realistically, they may not completely satisfy our hypotheses on how complex and diverse conditions - such as health status, life style, diet and nutrition - can actually interrelate in the life course of an individual.In this study we present and discuss evidences from Isola Sacra and Velia, two Roman Imperial Age coastal towns. The õ15N and õ13C values are compared with demographic and health status parameters, such as age, sex, stature, auricular exostoses, DISH, cribra orbitalia, enamel defects.

The fetal remains from the Ostuni 1 burial (Italy, ca 27 ka) represent a unique opportunity to explore the prenatal biological parameters, and to reconstruct the possible patho-biography, of a fetus (and its mother) in an Upper Paleolithic context. Phase-contrast synchrotron X-ray microtomography imaging of two deciduous tooth crowns and microfocus CT measurements of the right hemimandible of the Ostuni 1b fetus were performed at the SYRMEP beamline and at the TomoLab station of the Elettra - Sincrotrone laboratory (Trieste, Italy) in order to refine age at death and to report the enamel developmental history and dental tissue volumes for this fetal individual. The virtual histology allowed to estimate the age at death of the fetus at 31–33 gestational weeks. Three severe physiological stress episodes were also identified in the prenatal enamel. These stress episodes occurred during the last two months and half of pregnancy and may relate to the death of both individuals. Compared with modern prenatal standards, Os1b’s skeletal development was advanced. This cautions against the use of modern skeletal and dental references for archaeological finds and emphasizes the need for more studies on prenatal archaeological skeletal samples.