Constantine L. Karras

Constantine L. Karras

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Constantine L. Karras

Department of Neurological Surgery, Malnati Brain Tumor Institute, Northwestern University, Chicago, IL 60611, USA

Research Focus & Metrics

Academic Career Length

10Years (2017-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 November 2020 in Neurosurgical Focus
Verified
Journal Article
Closed access
PDF file
CLCollin J. Larkin
Collin J. Larkin
ARAnastasios G. Roumeliotis
Anastasios G. Roumeliotis
CKConstantine L. Karras
Constantine L. Karras
NMNikhil K. Murthy
Nikhil K. Murthy
MKMaria Fay Karras
Maria Fay Karras
MPMatthew B. Potts
Matthew B. Potts
Annually, 20% of all practicing neurosurgeons in the United States are faced with medical malpractice litigation. The average indemnity paid in a closed neurosurgical civil claim is $439,146, the highest of all medical specialties. The majority of claims result from dissatisfaction following spinal surgery, although claims after cranial surgery tend to be costlier. On a societal scale, the increasing prevalence of medical malpractice claims is a catalyst for the practice of defensive medicine, resulting in record-level healthcare costs. Outside of the obvious financial strains, malpractice claims have also been linked to professional disenchantment and career changes for afflicted physicians. Unfortunately, neurosurgical residents receive minimal practical education regarding these matters and are often unprepared and vulnerable to these setbacks in the earlier stages of their careers. In this article, the authors aim to provide neurosurgical residents and junior attendings with an introductory guide to the fundamentals of medical malpractice lawsuits and the implications for neurosurgeons as an adjunct to more formal residency education.

1 September 2017 in World Neurosurgery
Verified
Journal Article
Closed access
CKConstantine L. Karras
Constantine L. Karras
HTHuy Tran
Huy Tran
DDDavid Dornbos
David Dornbos
PNPhong Nguyen
Phong Nguyen
SNShahid Nimjee
Shahid Nimjee
CPCiarán J. Powers
Ciarán J. Powers

1 July 2019 in World Neurosurgery
Verified
Journal Article
Closed access
HTHuy Tran
Huy Tran
CKConstantine L. Karras
Constantine L. Karras
KYKetan Yerneni
Ketan Yerneni
STSiting J. Trybula
Siting J. Trybula
SVSon Tan Vo
Son Tan Vo
DPDaniel M Prevedello
Daniel M Prevedello

27 June 2023 in Cancers
Verified
Journal Article
Open access
PDF file
KNKhizar Rehan Nandoliya
Khizar Rehan Nandoliya
NSNishanth Sadagopan
Nishanth Sadagopan
VTVineeth Thirunavu
Vineeth Thirunavu
EHEthan Houskamp
Ethan Houskamp
CKConstantine L. Karras
Constantine L. Karras
Stephen T. MagillStephen T. Magill
Stephen T. Magill
Most of the literature on pineoblastoma consists of case reports and single-institution series. The goal of this systematic review and individual patient data (IPD) analysis was to summarize the existing literature, identify factors associated with overall survival (OS), and provide a contemporary update on prognosis for patients with pineoblastoma. Forty-four studies were identified with 298 patients having IPD. Kaplan–Meier analyses were used to report survival outcomes based on age, tumor metastases, extent of resection (EOR), adjuvant therapy, and publication year. Cox regression was performed to identify independent predictors of time to mortality. Multivariable recursive partitioning analysis was used to identify the most important subgroups associated with mortality. Patients were classified based on publication year before and after the last systematic review on this topic (pre-2012 and 2012 onwards) and compared using univariate and multivariable analyses. This study demonstrates that EOR less-than-gross total resection, metastatic presentation, adjuvant chemotherapy without radiation, and tumor presentation in children less than three years old are associated with poorer prognosis. Since 2012, the 5-year actuarial OS has improved from 32.8% to 56.1%, which remained significant even after accounting for EOR, age, and adjuvant therapy. Pineoblastoma remains a severe rare disease, but survival outcomes are improving.

1 April 2021 in Journal of Clinical Neuroscience
Verified
Journal Article
Closed access
KYKetan Yerneni
Ketan Yerneni
CKConstantine L. Karras
Constantine L. Karras
CLCollin J. Larkin
Collin J. Larkin
HWHannah Weiss
Hannah Weiss
BHBenjamin Hopkins
Benjamin Hopkins
OBOrin Bloch
Orin Bloch

1 December 2020 in Clinical Neurology and Neurosurgery
Verified
Journal Article
Closed access
CLCollin J. Larkin
Collin J. Larkin
ZAZachary A. Abecassis
Zachary A. Abecassis
KYKetan Yerneni
Ketan Yerneni
DNDominic A. Nistal
Dominic A. Nistal
CKConstantine L. Karras
Constantine L. Karras
NDNader S. Dahdaleh
Nader S. Dahdaleh