Introduction: Rheumatoid arthritis (RА) is an immune-inflammatory disease intrinsic to up to 1.0% of the world’s population. Standard drugs for RA therapy are basic medications, glucocorticoids and non-steroid anti-inflammatory drugs, which often only ease or hinder the course of disease, not curing the patient completely. Also, on the average 20-50 % of patients are unresponsive to treatment, allergic to the prescribed drugs or find them ineffective. That is why medications with a different mechanism of action are being widely researched, some of them being antagonists of proteinase-activated receptors (PAR-2). Materials and Methods: The inflammatory process was reproduced by injecting a 2% solution of neutral formalin in a volume of 0.1 mL under the aponeurosis of the posterior left foot. A total of 84 white rats were used in the experiment. Diclofenac sodium was administered as a reference drug. Results and Discussion: An experiment on researching the impact of 5 samples of derivatives of 4.5-dihydroisoxazol-5-carboxamide on formalin oedema development among rats showed that the compound R001, compared with other substances studied, differs in the late onset of the therapeutic effect when ingested; the restoration of the foot volume to the initial level occurs only after the introduction of R005, R004 and R002. R005 to a greater extent than other compounds prevents the development of edema and has greater therapeutic efficacy than diclofenac sodium both with intragastric administration and subcutaneous injection. Conclusion: All five compounds in question showed anti-inflammatory activity, with the spectrum not so unequivocal both in qualitative and quantitative values.

Introduction: The necessity of extra medicamental stimulation of bone tissue regeneration in addition to basic surgical method of treating fractures is usually determined by osteoporosis or high severity of injury. One of the lesser-studied options for osteogenic hormone therapy of fractures is the use of human chorionic gonadotropin(hCG). The aim of the study: Conducting an experimental evaluation of the osteogenic activity of hCG in its systemic and local application based on a model of perforated fracture of femoral bone in laboratory white rats. Materials and Methods: The experimental perforated femoral fracture in 64 male Wistar laboratory rats was modeled by drilling a circular bone defect with a 1.4 mm diameter. The osteogenic effect of the studied hormonal drugs (hCG and thyrocalcitonin) compared with a reference agent from the bisphosphonate group – zoledronic acid, after a course of injectable treatment was assessed according to the rate of bone defect recovery using digital radiography. In addition, the same method was used to experimentally evaluate the local osteogenic activity of hCGand zoledronate introduced into the bone marrow canal of the damaged bone via a patented original intramedullary metal construction for osteosynthesis. Results and Discussion: Upon administering the studied hormonal drugs by injection, significant osteogenic activity was observed, with a more pronounced effect for hCG, although still inferior to that of the reference pharmacotherapy. The intra-bone local application of hCG showed results practically equal to the osteogenic effect of zoledronate. Conclusion: As a result of the experiment, a high therapeutic effect of hCG on bone tissue regeneration was discovered, which, with local application (intramedullary implants soaked in hCG solution with a concentration of 5000 IU/mL), reached the level of zoledronate’s effect (intramedullary implants soaked in solution with a concentration of 0.8 mg/mL), but without the toxic side effects typically associated with the reference pharmacotherapy.

Experimental study of organ‑protective activity of peptide drugs under intoxication induced by a combination of first‑line antituberculosis agents | Smirnov | Patient-Oriented Medicine and Pharmacy Экспериментальное исследование органопротекторной активности некоторых пептидных препаратов в условиях интоксикации, спровоцированной комплексом основных противотуберкулезных средств | Смирнов | Пациентоориентированная медицина и фармация

Introduction: Drug-induced hepatitis is common in clinical practice. This problem is particularly relevant in the treatment of tuberculous infection, because for this purpose, up to 5–6 hepatotoxic drugs are used simultaneously for a long time, which often (in 15–20% of cases) leads to medical liver lesion. To protect the liver, Semax and Selank are offered – drugs of regulatory peptides group. Materials and Methods: The research was conducted on 96 outbred white male rats weighing 180–220 g. The experimental group included about 10 animals. Drug-induced hepatitis was simulated through the combined 21-day administration of isoniazid, rifampicin and ethanol. Semax and Selank, as well as Essentiale N and Mexidol (comparison drugs) were administered once a day during the experiment. Healthy control animals with experimental hepatitis were used for comparison. Subsequently, the obtained biochemical and histomorphological parameters were evaluated. Results and Discussion: In the experiment, Semax and Selank showed a greater therapeutic activity than the recognized hepatoprotectors – Essentiale and Mexidol. Only in the case of administering Selank and Semax, there was parallelism between the restoration of biochemical parameters of blood and histomorphological parameters of the liver. Selank was also characterized by an increased activity of regenerative processes. Conclusion: Administering Selank and Semax to patients with tuberculosis would significantly reduce the number and severity of hepatotoxic reactions.