Objective: This article aims to consolidate and synthesize existing knowledge on the fundamental principles and interdisciplinary approaches of palliative care, identifying gaps in literature and exploring collaborative improvements across medical specialties to enhance clinical outcomes and quality of life for patients in advanced disease stages. Theoretical Framework: Palliative care is essential for integrated patient management in serious illnesses, focusing on alleviating suffering and significantly enhancing quality of life. Method: A systematic review was conducted using major scientific databases to gather relevant articles on palliative care, utilizing specific keywords to identify studies on its principles and interdisciplinary approaches. This facilitated the synthesis of effective practices and the identification of research gaps, supporting evidence-based clinical practices. Results and Discussion: The review highlights that interdisciplinary approaches in palliative care significantly improve patient quality of life by addressing medical and psychosocial needs. It also shows a strong correlation between early palliative care integration and improved outcomes for patients and families. However, gaps in practice uniformity and integration of non-medical support services suggest areas for future research and improvement.

Objective: The objective of this article is to conduct a comprehensive review of recent advances in understanding the pathogenesis of Alzheimer's disease (AD) and innovations in its management, emphasizing how these developments can inform more effective therapeutic strategies. Initially, this study explores contemporary findings related to the molecular and cellular mechanisms contributing to AD pathology, including the aggregation of beta-amyloid and tau, neural inflammation, synaptic dysfunction, as well as the impact of genetic and environmental factors. Theoretical Framework: Alzheimer's disease (AD) presents itself as a growing challenge for global public health, given its rising prevalence and the significant impact on the affected individuals, their families, and the healthcare systems. Method: A systematic review was conducted using major scientific databases to collect relevant articles on recent advances in the understanding and management of Alzheimer's disease, from pathogenesis to treatment. Specific keywords were used to identify studies addressing new findings and interdisciplinary therapeutic strategies. This enabled the synthesis of effective approaches and the identification of research gaps, supporting evidence-based clinical practices. Results and Discussion: Recent research has identified novel genetic markers linked to Alzheimer's disease, enhancing early diagnosis. Studies have also demonstrated the efficacy of integrated cognitive therapies in slowing disease progression. Additionally, new pharmacological treatments targeting amyloid plaques have shown promise in clinical trials. However, challenges in uniform treatment efficacy across diverse populations highlight the need for tailored therapeutic approaches.