Food loss and waste occur throughout the food supply chain and represent food security and environmental, economic, and societal problems. Fresh fruit and vegetables contribute to over 40% of global food loss and waste. A significant portion of fruit and vegetables loss takes place on the farm during postharvest handling in developing countries, which is linked to smallholders’ financial and geographic constraints in purchasing modern postharvest handling technologies. While in developed countries, waste is the main problem identified at the retail and consumption levels because of inadequate logistics management, storage, and consumer behavior. The loss and waste deprive the population of a significant quantity of healthy food. To address this challenge, cost-effective, easy-to-use, and affordable approaches could be supplied to stakeholders. These strategies encompass the utilization of shading, low-cost packaging, porous evaporative cooling, zero-energy cooling chambers, and pot-in-pot coolers, for reductions in loss in developing countries. Meanwhile, in developed countries, biosensors, 1-methylcyclopropene, and imaging processing are employed to assess the quality of fresh fruit and vegetables at both retail and consumer levels. By exploring these methods, the review aims to provide smallholders, retailers, and consumers with efficient methods for improving produce operating techniques, resulting in reduced losses and waste and higher income.