Background: Artificial intelligence (AI) has the potential to enhance clinical decision-making, including in infectious diseases. By improving antimicrobial resistance prediction and optimizing antibiotic prescriptions, these technologies may support treatment strategies and address critical gaps in healthcare. This study evaluates the effectiveness of AI in guiding appropriate antibiotic prescriptions for infectious diseases through a systematic literature review. Methods: We conducted a systematic review of studies evaluating AI (machine learning or large language models) used for guidance on prescribing appropriate antibiotics in infectious disease cases. Searches were performed in PubMed, CINAHL, Embase, Scopus, Web of Science, and Google Scholar for articles published up to October 25, 2024. Inclusion criteria focused on studies assessing the performance of AI in clinical practice, with outcomes related to antimicrobial management and decision-making. Results: Seventeen studies used machine learning as part of clinical decision support systems (CDSS). They improved prediction of antimicrobial resistance and optimized antimicrobial use. Six studies focused on large language models to guide antimicrobial therapy; they had higher prescribing error rates, patient safety risks, and needed precise prompts to ensure accurate responses. Conclusions: AI, particularly machine learning integrated into CDSS, holds promise in enhancing clinical decision-making and improving antimicrobial management. However, large language models currently lack the reliability required for complex clinical applications. The indispensable role of infectious disease specialists remains critical for ensuring accurate, personalized, and safe treatment strategies. Rigorous validation and regular updates are essential before the successful integration of AI into clinical practice.

This review examines the experimental evidence regarding unilateral resistance training frequency, intensity, the type of training, training volume, and adjuvant therapies on the cross-education of strength. CINAHL, MEDLINE, APA PsycInfo, SPORTDiscus, and Web of Science were systematically searched with gray literature searches and pearling of references thereafter. Experiments were included in the review if they performed a unilateral resistance training intervention that directly compared the dose of a training variable on the cross-education response in healthy or clinical populations following a minimum of two weeks of training. Experiments must have reported maximal strength outcomes for the untrained limb. For each experiment, the study population, intervention methods, the dosage of the training variable being studied, and the outcomes for the untrained, contralateral limb were identified and collectively synthesized. The search returned a total of 912 articles, 57 of which qualified for inclusion. The results show that experimental trials have been conducted on resistance training frequency ( n = 4), intensity ( n = 7), the type of training ( n = 26), training volume ( n = 3), and adjuvant therapies ( n = 17) on the cross-education of strength. This review maps the available evidence regarding exercise design and prescription strategies to promote the cross-education of strength. It appears that traditional resistance training frequencies (i.e., 2–3×/week) at high intensities are effective at promoting cross-education with eccentric muscle actions showing additive benefits. There is experimental evidence that neuromodulatory techniques can augment cross-education when layered with unilateral resistance training versus training alone. Registration identifier (osf.io/9sh5b). The cross-education of strength is moderated by exercise design and prescription in clinical and non-clinical populations. This review synthesizes the available evidence regarding exercise design strategies for unilateral resistance training and provides evidence-based recommendations for the prescription of unilateral training to maximize the cross-education of strength. Greater insights regarding the timing and effectiveness of cross-education interventions in clinical scenarios will strengthen the use of unilateral resistance training for individuals who may benefit from its use.

This paper reviews the results of a qualitative metasummary exploring parents’ experiences of a transgender and gender nonconforming (TGNC) child’s initial identity disclosure conversations or the parent’s initial awareness of their child’s gender identity. We conducted a systematic literature search, resulting in 22 peer-reviewed articles with qualitative data collected from parent participants. Data analysis resulted in two primary themes, five subthemes, and 25 total findings, which we describe in the findings section. The discussion section articulates how these findings may benefit healthcare providers serving parents and their TGNC identified children. This paper concludes with an invitation for healthcare providers to provide services that address the needs of TGNC children, parents, and the relational bond existing between them.

Background: Parents seek support on behalf of their transgender and gender nonconforming (TGNC) children. Previous qualitative studies explore the types of support parents seek inside and outside of healthcare settings. Healthcare providers often remain unprepared to effectively provide gender-affirming services to TGNC children and their accompanying parents and may benefit from learning about the support seeking experiences of parents with TGNC children. Aims: This paper summarized qualitative research studies that address the topic of parents seeking support on behalf of their TGNC children. We produced this report for healthcare providers to review to enhance gender-affirming services for parents and TGNC children. Methods: This paper outlines a qualitative metasummary of studies from the United States or Canada with data collected from parents of TGNC children. Data collection included the steps of journal runs, database searches, reference checks, and area scans. Data analysis involved the steps of extracting, editing, grouping, abstracting, and calculating the intensity and frequency effect sizes for finding statements from qualitative research study articles. Results: The results of this metasummary yielded two primary themes, six subthemes, and 24 total findings. The first primary theme of seeking guidance had three subthemes: educational resources, community networks, and advocacy efforts. The second primary theme of seeking healthcare had three subthemes: healthcare providers, mental healthcare, and general healthcare. Discussion: These findings provide information healthcare providers can use to inform their practice. These findings also highlight the importance of providers working collaboratively with parents when serving TGNC children. This article concludes with practical tips for providers.

This systematic literature review explores parents of transgender and gender nonconforming (TGNC) children’s experiences interfacing with members of their social support networks. We used the qualitative metasummary literature review analysis method to collect and examine peer-reviewed empirical studies, including qualitative data collected from parents of TGNC children. From 20 relevant academic articles, we identified two themes, seven subthemes, and 26 findings. In this paper, we present the findings of our metasummary and share implications for healthcare providers to consider in their practice with TGNC children and accompanying parents.

This article outlines a qualitative metasummary of studies with qualitative findings collected from parents of transgender and gender-nonconforming (TGNC) children. This literature review study describes parents’ experiences of responding to TGNC children. The step of data analysis for this study resulted in a data set of 34 research articles with two primary themes, four subthemes, and 17 findings. The two primary themes represent challenges parents faced and changes they made relating to their TGNC children. We created this report to share with mental health professionals, such as clinical social workers, serving TGNC children and their parents. This metasummary report concludes with recommendations mental health professionals can implement to improve services offered to TGNC child mental health care recipients and their accompanying parents.