Brenda Palomar de Lucas

Dr. Brenda Palomar de Lucas

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Biography

I am a Doctor of Medicine and researcher at INCLIVA Biomedical Research Institute (Hospital Clínico Universitario de Valencia, Spain), where I am a member of the Colorectal Cancer Research Group within the Anatomical Pathology Laboratory. My academic background spans Chemistry and Anatomical Pathology, providing a strong interdisciplinary foundation in both molecular and morphological approaches to cancer research. My research focuses on the characterization of the tumor microenvironment in microsatellite-stable colorectal cancer, with particular interest in the immune and stromal components that drive disease progression and resistance to immunotherapy. I have expertise in high-resolution spatial transcriptomics (Visium HD), bulk RNA sequencing, and integrative multi-omic approaches applied to formalin-fixed paraffin-embedded tumor tissue. My work aims to identify prognostic biomarkers and therapeutic targets within macrophage-enriched stromal niches, with a focus on the interplay between epithelial-to-mesenchymal transition programs and immune activation states.

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