Using socioecological concepts and within a historical biodiversity conservation context, this research study reviews the main interactions between human communities and protected natural areas (PNAs) to describe their different stages over time and assess the implications arising from climate change. The review suggests that both society and governments have raised awareness and interest regarding the importance of biodiversity conservation. The interactions of human communities in these areas have had different effects on biodiversity use, management, and conservation. Local communities have historically developed traditional uses of natural resources that allow them to remain over time and conserve them. Thus, the interest in PNAs as a conservation instrument has increased worldwide. Regarding climate change, this study found evidence indicating that PNAs may act as buffer barriers to prevent biodiversity loss and mitigate the impacts of extreme events; nevertheless, a great variation can be expected. The magnitude of the impacts on human communities, levels of vulnerability, and resilience capacity of PNAs facing climate change (CC) rely on many factors, such as location, extent, composition, management, and ecology of a given protected area. Therefore, the new scenarios that CC may bring are challenging current systematic conservation planning and traditional management methods of the natural resources that are vital for people. Finally, the authors suggest that society is increasingly aware of PNAs as one of the best tools humans have to prevent biodiversity loss, and potentially buffer the effects of CC. These increases in social awareness of biodiversity conservation importance and PNAs are gratifying and spread optimism about the future that next generations may face.