This article reviews the autonomous manipulation strategies of biological cells utilizing optical tweezers, mainly including optical direct and indirect manipulation strategies. The typical and latest achievements in the optical manipulation of cells are presented, and the existing challenges for autonomous optical manipulation of biological cells are also introduced. Moreover, the integrations of optical tweezers with other manipulation tools are presented, which broadens the applications of optical tweezers in the biomedical manipulation areas and will also foster new developments in cell-based physiology and pathology studies, such as cell migration, single cell surgery, and preimplantation genetic diagnosis (PGD).

Brain computer interface (BCI) adopts human brain signals to control external devices directly without using normal neural pathway. Recent study has explored many applications, such as controlling a teleoperation robot by electroencephalography (EEG) signals. However, utilizing the motor imagery EEG-based BCI to perform teleoperation for reach and grasp task still has many difficulties, especially in continuous multidimensional control of robot and tactile feedback. In this research, a motor imagery EEG-based continuous teleoperation robot control system with tactile feedback was proposed. Firstly, mental imagination of different hand movements was translated into continuous command to control the remote robotic arm to reach the hover area of the target through a wireless local area network (LAN). Then, the robotic arm automatically completed the task of grasping the target. Meanwhile, the tactile information of remote robotic gripper was detected and converted to the feedback command. Finally, the vibrotactile stimulus was supplied to users to improve their telepresence. Experimental results demonstrate the feasibility of using the motor imagery EEG acquired by wireless portable equipment to realize the continuous teleoperation robot control system to finish the reach and grasp task. The average two-dimensional continuous control success rates for online Task 1 and Task 2 of the six subjects were 78.0% ± 6.1% and 66.2% ± 6.0%, respectively. Furthermore, compared with the traditional EEG triggered robot control using the predefined trajectory, the continuous fully two-dimensional control can not only improve the teleoperation robot system’s efficiency but also give the subject a more natural control which is critical to human–machine interaction (HMI). In addition, vibrotactile stimulus can improve the operator’s telepresence and task performance.

Brain-computer interfaces (BCIs) have achieved successful control of assistive devices, e.g. neuroprosthesis or robotic arm. Previous research based on hand movements Electroencephalogram (EEG) has shown limited success in precise and natural control. In this study, we explored the possibilities of decoding movement types and kinematic information for three reach-and-execute actions using movement-related cortical potentials (MRCPs). EEG signals were acquired from 12 healthy subjects during the execution of pinch, palmar and precision disk rotation actions that involved two levels of speeds and forces. In the case of discrimination between hand movement types under each of four different kinematics conditions, we obtained the average peak accuracies of 83.44% and 73.83% for the binary and 3-class classification, respectively. In the case of discrimination between different movement kinematics for each of three actions, the average peak accuracies of 82.9% and 58.2% could be achieved for the two and 4-class scenario. In both cases, peak decoding performance was significantly higher than the subject-specific chance level. We found that hand movement types all could be classified when these actions were executed at four different kinematic parameters. Meanwhile, for each of three hand movements, we decoded movement parameters successfully. Furthermore, the feasibility of decoding hand movements during hand retraction process was also demonstrated. These findings are of great importance for controlling neuroprosthesis or other rehabilitation devices in a fine and natural way, which would drastically increase the acceptance of motor impaired users.

Surface electromyography (sEMG) signals are widely used in the recognition of hand gestures. Nowadays, researchers usually increase the number of sEMG signal measurement positions and extract multiple features to improve the recognition accuracy. In this paper, we propose a sEMG measurement position and feature optimization strategy for gesture recognition based on Analysis of Variance (ANOVA) and neural networks. Firstly, four channels of raw sEMG signals are acquired, and four time-domain features are extracted. Then different neural networks are trained and tested by using different data sets which are obtained based on the combination of different measurement positions and features. Finally, ANOVA and Tukey HSD testing are conducted based on the gesture recognition results of different neural networks. We obtain the optimal measurement position sets for gesture recognition when different feature sets are used, and similarly, the optimal feature sets when different measurement position sets are used. Our experimental results show that the feature set of zero crossing and integrated sEMG provides the highest gesture recognition accuracy, which is 94.83%, when four channels of sEMG signals are used; the optimal measurement position set when four sEMG signal features are used for hand gesture recognition is P1+P3+P4, which provides an accuracy of 94.6%.

In traditional hand function assessment, patients and physicians always need to accomplish complex activities and rating tasks. This paper proposes a novel wearable glove system for hand function assessment. A sensing system consisting of 12 nine-axis inertial and magnetic unit (IMMU) sensors is used to obtain the acceleration, angular velocity, and geomagnetic orientation of human hand movements. A complementary filter algorithm is applied to calculate the angles of joints after sensor calibration. A virtual hand model is also developed to map with the glove system in the Unity platform. The experimental results show that this glove system can capture and reproduce human hand motions with high accuracy. This smart glove system is expected to reduce the complexity and time consumption of hand kinematics assessment.

Capturing finger joint angle information has important applications in human–computer interaction and hand function evaluation. In this paper, a novel wearable data glove is proposed for capturing finger joint angles. A sensing unit based on a grating strip and an optical detector is specially designed for finger joint angle measurement. To measure the angles of finger joints, 14 sensing units are arranged on the back of the glove. There is a sensing unit on the back of each of the middle phalange, proximal phalange, and metacarpal of each finger, except for the thumb. For the thumb, two sensing units are distributed on the back of the proximal phalange and metacarpal, respectively. Sensing unit response tests and calibration experiments are conducted to evaluate the feasibility of using the designed sensing unit for finger joint measurement. Experimental results of calibration show that the comprehensive precision of measuring the joint angle of a wooden finger model is 1.67%. Grasping tests and static digital gesture recognition experiments are conducted to evaluate the performance of the designed glove. We achieve a recognition accuracy of 99% by using the designed glove and a generalized regression neural network (GRNN). These preliminary experimental results indicate that the designed data glove is effective in capturing finger joint angles.