The Chiang Lab of Intestinal Immunobiology and Inflammation has particular interests in understanding how the intestinal immune system recognizes and responds to microbial molecules and endogenous signals; and how alterations in inflammatory responses contribute to the biology and pathogenesis of Inflammatory Bowel Disease (IBD). We aim to elucidate the molecular and cellular mechanisms by which intestinal immune cells control and respond to infections and endogenous innocuous signals in maintaining dynamic intestinal homeostasis. We have developed a research program that integrates immunology, cell biology, systems biology, genetics, high-resolution imaging, and several experimental mouse models to interrogate the roles of intestinal neutrophils, mononuclear phagocytes (dendritic cells and macrophages), and epithelial cells in IBD susceptibility. ​The ultimate goal of our research is to attenuate undesirable inflammation and to modulate the mediators involved in the resolution of inflammation in the gut to treat patients with IBD.