Dr. Chong Liu
chemistry and biochemistry, Texas Tech University, Lubbock, Texas, USA
'%3e%3cpath%20d='M22.1642%2019.0924C21.7317%2018.068%2021.1041%2017.1375%2020.3163%2016.3527C19.5309%2015.5656%2018.6006%2014.9381%2017.5766%2014.5048C17.5674%2014.5002%2017.5582%2014.4979%2017.5491%2014.4933C18.9774%2013.4616%2019.9059%2011.7811%2019.9059%209.88504C19.9059%206.74408%2017.3611%204.19922%2014.2201%204.19922C11.0792%204.19922%208.53429%206.74408%208.53429%209.88504C8.53429%2011.7811%209.46282%2013.4616%2010.8912%2014.4956C10.882%2014.5002%2010.8728%2014.5025%2010.8636%2014.5071C9.83652%2014.9404%208.91487%2015.5617%208.1239%2016.355C7.33685%2017.1404%206.70933%2018.0707%206.276%2019.0947C5.85031%2020.0972%205.62072%2021.172%205.59967%2022.2609C5.59905%2022.2853%205.60335%2022.3097%205.61229%2022.3325C5.62123%2022.3553%205.63465%2022.376%205.65174%2022.3935C5.66883%2022.4111%205.68926%2022.425%205.71182%2022.4345C5.73437%2022.444%205.7586%2022.4489%205.78308%2022.4489H7.15868C7.25956%2022.4489%207.3398%2022.3686%207.3421%2022.2701C7.38795%2020.5001%208.09868%2018.8425%209.35506%2017.5861C10.655%2016.2862%2012.3814%2015.5709%2014.2201%2015.5709C16.0588%2015.5709%2017.7852%2016.2862%2019.0852%2017.5861C20.3415%2018.8425%2021.0523%2020.5001%2021.0981%2022.2701C21.1004%2022.3709%2021.1807%2022.4489%2021.2815%2022.4489H22.6571C22.6816%2022.4489%2022.7058%2022.444%2022.7284%2022.4345C22.751%2022.425%2022.7714%2022.4111%2022.7885%2022.3935C22.8056%2022.376%2022.819%2022.3553%2022.8279%2022.3325C22.8369%2022.3097%2022.8412%2022.2853%2022.8406%2022.2609C22.8176%2021.165%2022.5907%2020.0989%2022.1642%2019.0924ZM14.2201%2013.8284C13.1678%2013.8284%2012.1773%2013.418%2011.4322%2012.6729C10.6871%2011.9278%2010.2767%2010.9374%2010.2767%209.88504C10.2767%208.83271%2010.6871%207.84227%2011.4322%207.09715C12.1773%206.35204%2013.1678%205.94165%2014.2201%205.94165C15.2724%205.94165%2016.2629%206.35204%2017.008%207.09715C17.7531%207.84227%2018.1635%208.83271%2018.1635%209.88504C18.1635%2010.9374%2017.7531%2011.9278%2017.008%2012.6729C16.2629%2013.418%2015.2724%2013.8284%2014.2201%2013.8284Z'%20fill='%238590A2'/%3e%3c/g%3e%3c/svg%3e)
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Academic Career Length
6Years (2021-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 August 2022 in Green Synthesis and Catalysis
Journal Article
LTLong Tang
Long Tang
QHQingyue Hu
Qingyue Hu
KYKe Yang
Ke YangMEMazen Elsaid
Mazen ElsaidChong LiuHGHaibo Ge
Haibo Ge
28 January 2021 in Angewandte Chemie International Edition
Journal Article
Chong LiuJYJing Yuan
Jing Yuan
ZZZhenfeng Zhang
Zhenfeng Zhang
IGIlya D. Gridnev
Ilya D. Gridnev
WZWanbin Zhang
Wanbin ZhangJournal Article
KYKe Yang
Ke YangZLZhi Li
Zhi LiQHQingyue Hu
Qingyue HuMEMazen Elsaid
Mazen ElsaidChong Liu
Haibo Ge +1
N-heterocycles are ubiquitous in natural products, pharmaceuticals, organic materials, and numerous functional molecules. Among the current synthetic approaches, transition metal-catalyzed C–H functionalization has gained considerable attention in recent years due to its advantages of simplicity, high atomic economy, and the ready availability of starting materials. In the field of N-heterocycle synthesis via C–H functionalization, nickel has been recognized as one of the most important catalysts. In this review, we will introduce nickel-catalyzed intramolecular and intermolecular pathways for N-heterocycle synthesis from 2008 to 2021.
25 April 2022 in Chemical Science
Journal Article
KYKe Yang
Ke YangZLZhi Li
Zhi Li
Chong LiuYLYunjian Li
Yunjian Li
QHQingyue Hu
Qingyue Hu
Haibo Ge +5
The transient directing group (TDG) strategy allowed long awaited access to the direct β-C(sp3)–H functionalization of unmasked aliphatic aldehydes via palladium catalysis. However, the current techniques are restricted to terminal methyl functionalization, limiting their structural scopes and applicability. Herein, we report the development of a direct Pd-catalyzed methylene β-C–H arylation of linear unmasked aldehydes by using 3-amino-3-methylbutanoic acid as a TDG and 2-pyridone as an external ligand. Density functional theory calculations provided insights into the reaction mechanism and shed light on the roles of the external and transient directing ligands in the catalytic transformation.
Journal Article
DYDan Yuan
Dan YuanZXziting xu
ziting xuYZYang Zhou
Yang ZhouFHFaith Herington
Faith HeringtonChong LiuHaibo Ge +1
Heterocycles are widely present in natural products, pharmaceuticals, and organic functional materials. In heterocycle synthesis, Pd-catalyzed cascade C–H functionalization has been regarded as one of the most powerful approaches due to its advantages in terms of high atom efficiency and readily available starting materials. In this review, we will briefly introduce the major advances in palladium-catalyzed cascade C(sp3)–H activation and annulation for constructing different types of heterocycles through inter- and intramolecular pathways from 2010 to 2023.
Journal Article
QLQin Li
Qin LiDYDan Yuan
Dan YuanChong LiuFHFaith Herington
Faith HeringtonKYKe Yang
Ke YangHaibo GeA metal-free and Selectfluor-mediated selective oxidation reaction of benzo[d]isothiazol-3(2H)-ones in aqueous media is presented. This novel strategy provides a facile, green, and efficient approach to access important benzo[d]isothiazol-3(2H)-one-1-oxides with excellent yields and high tolerance to various functional groups. Furthermore, the purification of benzoisothiazol-3-one-1-oxides does not rely on column chromatography. Moreover, the preparation of saccharine derivatives has been achieved through sequential, double oxidation reactions in a one-pot aqueous media.
About Me
Dr. Chong Liu received his Bachelor's and Master's degrees from Huazhong University of Science and Technology, followed by a Ph.D. in organic chemistry from Shanghai Jiao Tong University in 2020. Then, I joined the research group of Professor Haibo Ge at Texas Tech University as a postdoctoral researcher. My research lies at the interface of organic synthesis and catalysis, with a particular emphasis on the development of transition metal-catalyzed strategies for the efficient and selective construction of complex molecular architectures. Key areas of focus include the transition metal catalysis, organometallic chemistry, asymmetric synthesis, and the development of synthetic methodologies for deuterated pharmaceuticals.