Sprinting is often seen in a variety of sports. Focusing one’s attention externally before sprinting has been demonstrated to boost sprint performance. The present study aimed to systematically review previous findings on the impact of external focus (EF), in comparison to internal focus (IF), on sprint performance. A literature search was conducted in five electronic databases (APA PsycINFO, PubMed, Scopus, SPORTDiscus, and Web of Science). A random-effects model was used to pool Hedge’s g with 95% confidence intervals (CIs). The meta-analysis included six studies with a total of 10 effect sizes and 166 participants. In general, the EF condition outperformed the IF condition in sprint performance (g = 0.279, 95% CI [0.088, 0.470], p = 0.004). The subgroup analysis, which should be viewed with caution, suggested that the benefits associated with the EF strategy were significant in low-skill sprinters (g = 0.337, 95% CI [0.032, 0.642], p = 0.030) but not significant in high-skill sprinters (g = 0.246, 95% CI [−0.042, 0.533], p = 0.094), although no significant difference was seen between these subgroups (p = 0.670). The reported gain in sprint performance due to attentional focus has practical implications for coaches and athletes, as making tiny adjustments in verbal instructions can lead to significant behavioral effects of great importance in competitive sports.