Aiming at the problem of low operating efficiency due to the poor endurance of plant protection rotor drones and the small volume of pesticide carried, this paper proposes a route-planning algorithm for convex polygon regions based on the initial heading angle. First, a series of coordinate conversion methods ranging from the Earth coordinate system to the local plane coordinate system are studied. Second, in the local plane coordinate system, a route generation method based on subregion is proposed; therefore, multiple routes can be generated with different initial heading angles. Lastly, the optimal route and the best initial heading angle can be obtained after the comparison according to the three evaluation criteria: number of turns, route distance, and pesticide waste rate. The simulation results show that, compared with the common grid method, the route generation method based on subregion reduces the route distance and pesticide waste rate by 2.27% and 13.75%, respectively. Furthermore, it also shows that, compared with the route generated by the initial heading angle of 0°, the optimal route reduces the number of turns, route distance, and pesticide waste rate by 60%, 17.65%, and 38.18%, respectively. The route was optimized in three aspects and reached the best overall result using this method, which in turn proved its feasibility.